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PXD004376

PXD004376 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSRM quantitative analysis of patients CSF
DescriptionMultiple sclerosis is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system. In most patients, the disease initiates with an episode of neurological disturbance referred to as clinically isolated syndrome, but not all patients with this syndrome develop multiple sclerosis over time, and currently, there is no clinical test that can conclusively establish whether a patient with a clinically isolated syndrome will eventually develop clinically defined multiple sclerosis. Here, we took advantage of the capabilities of targeted mass spectrometry to establish a diagnostic molecular classifier with high sensitivity and specificity able to differentiate between clinically isolated syndrome patients with a high and a low risk of developing multiple sclerosis. Based on the combination of abundances of proteins chitinase 3-like 1 and ala-Ã-his-dipeptidase in cerebrospinal fluid we built a statistical model able to assign to each patient a precise probability of conversion to clinically defined multiple sclerosis. Our results are of special relevance for patients affected by multiple sclerosis as early treatment can prevent brain damage and slow down the disease progression
HostingRepositoryPeptideAtlas
AnnounceDate2016-06-20
AnnouncementXMLSubmission_2016-06-20_14:33:02.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEva Borras
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList6x(13)C,4x(15)N labeled L-arginine; 6x(13)C,2x(15)N labeled L-lysine; S-carboxamidomethyl-L-cysteine
InstrumentQTRAP 5500
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-06-20 14:30:44ID requested
12016-06-20 14:33:03announced
Publication List
Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, M, ö, ller T, Hornstein E, Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J, 34(21):2633-51(2015) [pubmed]
Keyword List
curator keyword: selected reaction monitoring, SRM, targeted
Contact List
Eva Borras
contact affiliationUniversity Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG)
contact emaileva.borras@upf.edu
dataset submitter
Eduard Sabidó
contact affiliationUniversity Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG)
contact emaileduard.sabido@crg.eu
lab head
Full Dataset Link List
PeptideAtlas dataset URI
PASSEL experiment URI
PASSEL transition group browser URI