PXD004376

PXD004376 is an original dataset announced via ProteomeXchange.

Title	SRM quantitative analysis of patients CSF
Description	Multiple sclerosis is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system. In most patients, the disease initiates with an episode of neurological disturbance referred to as clinically isolated syndrome, but not all patients with this syndrome develop multiple sclerosis over time, and currently, there is no clinical test that can conclusively establish whether a patient with a clinically isolated syndrome will eventually develop clinically defined multiple sclerosis. Here, we took advantage of the capabilities of targeted mass spectrometry to establish a diagnostic molecular classifier with high sensitivity and specificity able to differentiate between clinically isolated syndrome patients with a high and a low risk of developing multiple sclerosis. Based on the combination of abundances of proteins chitinase 3-like 1 and ala-Ã-his-dipeptidase in cerebrospinal fluid we built a statistical model able to assign to each patient a precise probability of conversion to clinically defined multiple sclerosis. Our results are of special relevance for patients affected by multiple sclerosis as early treatment can prevent brain damage and slow down the disease progression
HostingRepository	PeptideAtlas
AnnounceDate	2016-06-20
AnnouncementXML	Submission_2016-06-20_14:33:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eva Borras
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	6x(13)C,4x(15)N labeled L-arginine; 6x(13)C,2x(15)N labeled L-lysine; S-carboxamidomethyl-L-cysteine
Instrument	QTRAP 5500

Revision	Datetime	Status	ChangeLog Entry
0	2016-06-20 14:30:44	ID requested
⏵ 1	2016-06-20 14:33:03	announced

Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, M, ö, ller T, Hornstein E, Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J, 34(21):2633-51(2015) [pubmed]

curator keyword: selected reaction monitoring, SRM, targeted

Eva Borras
contact affiliation	University Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG)
contact email	eva.borras@upf.edu
dataset submitter
Eduard Sabidó
contact affiliation	University Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG)
contact email	eduard.sabido@crg.eu
lab head

PeptideAtlas dataset URI

PASSEL experiment URI

PASSEL transition group browser URI