PXD004376
PXD004376 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | SRM quantitative analysis of patients CSF |
Description | Multiple sclerosis is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system. In most patients, the disease initiates with an episode of neurological disturbance referred to as clinically isolated syndrome, but not all patients with this syndrome develop multiple sclerosis over time, and currently, there is no clinical test that can conclusively establish whether a patient with a clinically isolated syndrome will eventually develop clinically defined multiple sclerosis. Here, we took advantage of the capabilities of targeted mass spectrometry to establish a diagnostic molecular classifier with high sensitivity and specificity able to differentiate between clinically isolated syndrome patients with a high and a low risk of developing multiple sclerosis. Based on the combination of abundances of proteins chitinase 3-like 1 and ala-Ã-his-dipeptidase in cerebrospinal fluid we built a statistical model able to assign to each patient a precise probability of conversion to clinically defined multiple sclerosis. Our results are of special relevance for patients affected by multiple sclerosis as early treatment can prevent brain damage and slow down the disease progression |
HostingRepository | PeptideAtlas |
AnnounceDate | 2016-06-20 |
AnnouncementXML | Submission_2016-06-20_14:33:02.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Eva Borras |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | 6x(13)C,4x(15)N labeled L-arginine; 6x(13)C,2x(15)N labeled L-lysine; S-carboxamidomethyl-L-cysteine |
Instrument | QTRAP 5500 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2016-06-20 14:30:44 | ID requested | |
⏵ 1 | 2016-06-20 14:33:03 | announced |
Publication List
Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, M, ö, ller T, Hornstein E, Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J, 34(21):2633-51(2015) [pubmed] |
Keyword List
curator keyword: selected reaction monitoring, SRM, targeted |
Contact List
Eva Borras | |
---|---|
contact affiliation | University Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG) |
contact email | eva.borras@upf.edu |
dataset submitter | |
Eduard Sabidó | |
contact affiliation | University Pompeu Fabra (UPF), Center for Genomic Regiulation (CRG) |
contact email | eduard.sabido@crg.eu |
lab head |
Full Dataset Link List
PeptideAtlas dataset URI |
PASSEL experiment URI |
PASSEL transition group browser URI |