PXD004342 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Expression Proteomics of BRAF Inhibitor Resistance in Melanoma Cell Lines |
Description | To investigate mechanisms of resistance to BRAF inhibitor therapy in melanoma, BRAF mutant cell lines have been chronically exposed to BRAFi to create phenotypes with acquired drug resistance. Expression proteomics is used to examine the differences between naive and drug-resistant cells. |
HostingRepository | PRIDE |
AnnounceDate | 2017-10-24 |
AnnouncementXML | Submission_2017-10-24_05:46:18.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | John Koomen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-06-16 04:04:47 | ID requested | |
1 | 2016-12-13 14:23:24 | announced | |
⏵ 2 | 2017-10-24 05:46:19 | announced | Updated project metadata. |
Publication List
Sharma R, Fedorenko I, Spence PT, Sondak VK, Smalley KS, Koomen JM, Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition. J Proteome Res, 15(12):4476-4489(2016) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Melanoma, BRAF, Kinase Inhibitor, Drug Resistance, TMT |
Contact List
John Koomen |
contact affiliation | Molecular Oncology Chemical Biology and Molecular Medicine Moffitt Cancer Center & Research Institute, SRB3 12902 Magnolia Drive, Tampa, FL, 33612, USA. |
contact email | john.koomen@moffitt.org |
lab head | |
John Koomen |
contact affiliation | Moffitt Cancer Center |
contact email | john.koomen@moffitt.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD004342 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004342
- Label: PRIDE project
- Name: Expression Proteomics of BRAF Inhibitor Resistance in Melanoma Cell Lines