PXD004319

PXD004319 is an original dataset announced via ProteomeXchange.

Title	Metaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls
Description	The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. Thus, the purpose of the present investigation was to compare metaproteomic profiles of saliva in oral health and disease. Stimulated saliva samples were collected from 10 patients with periodontitis, 10 patients with dental caries and 10 orally healthy individuals. Samples were analyzed by means of shotgun proteomics. 4161 different proteins were recorded out of which 1946 and 2090 were of bacterial and human origin respectively. The human proteomic profile displayed significant overexpression of the complement system and inflammatory mediators in periodontitis and dental caries. Bacterial proteomic profiles and functional annotation were very similar in health and disease. Data revealed multiple potential salivary proteomic biomarkers of oral disease. In addition, comparable bacterial functional profiles were observed in periodontitis, dental caries and oral health, which suggest that the salivary microbiota predominantly thrives in a planktonic state expressing no characteristic disease-associated metabolic activity. Future large-scale longitudinal studies are warranted to reveal the full potential of proteomic analysis of saliva as a biomarker of oral health and disease.
HostingRepository	PRIDE
AnnounceDate	2016-08-15
AnnouncementXML	Submission_2016-10-05_03:44:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rosa Jersie-Christensen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-06-13 03:16:46	ID requested
1	2016-08-15 07:41:13	announced
⏵ 2	2016-10-05 03:44:54	announced	Updated publication reference for PubMed record(s): 27672500.

Belstr, ø, m D, Jersie-Christensen RR, Lyon D, Damgaard C, Jensen LJ, Holmstrup P, Olsen JV, Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls. PeerJ, 4():e2433(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, Saliva, Metaproteomics, Q exactive HF

Jesper Velgaard Olsen
contact affiliation	University of Copenhagen Faculty of Health and Medical Sciences Novo Nordisk Foundation Center for Protein Research Proteomics Program
contact email	jesper.olsen@cpr.ku.dk
lab head
Rosa Jersie-Christensen
contact affiliation	University of Copenhagen
contact email	rosa.rjc@cpr.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD004319

PRIDE project URI

• PRIDE
  1. PXD004319
     1. Label: PRIDE project
     2. Name: Metaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls