PXD004284

PXD004284 is an original dataset announced via ProteomeXchange.

Title	Mouse Liver LC-MSMS - System-wide quantitative proteomics of the metabolic syndrome in mice: genotypic and dietary effects
Description	Advances in mass spectrometry have made the quantitative measurement of proteins across multiple samples a reality, allowing for the study of complex biological systems such as the metabolic syndrome. Although deregulation of lipid metabolism and increased hepatic storage of triacylglycerides are known to play a part in the onset of the metabolic syndrome, its molecular basis and dependency on dietary and genotypic factors are poorly characterized. Here, we used a rich experimental design with two different mouse strains, dietary and metabolic perturbations to generate a compendium of quantitative proteome data, using three mass spectrometry strategies. The data recapitulates known properties of the metabolic system and indicate differential molecular adaptation of the two mouse strains to perturbations, contributing to a better understanding of the metabolic syndrome. We show that high-quality, high-throughput proteomic datasets provide an unbiased broad overview of complex systems upon perturbation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:30:26.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eduard Sabidó
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2016-06-06 07:44:22	ID requested
1	2016-12-22 02:40:44	announced
2	2017-10-24 03:13:05	announced	Updated project metadata.
⏵ 3	2024-10-22 04:30:34	announced	2024-10-22: Updated project metadata.

Terfve C, Sabid, ó E, Wu Y, Gon, ç, alves E, Choi M, Vaga S, Vitek O, Saez-Rodriguez J, Aebersold R, System-Wide Quantitative Proteomics of the Metabolic Syndrome in Mice: Genotypic and Dietary Effects. J Proteome Res, 16(2):831-841(2017) [pubmed]

curator keyword: Biological

submitter keyword: mouse, liver

Ruedi Aebersold
contact affiliation	Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland Department of Science, Faculty of Science, University of Zürich, Zürich, Switzerland
contact email	aebersold@imsb.biol.ethz.ch
lab head
Eduard Sabidó
contact affiliation	Centre de Regulació Genòmica
contact email	eduard.sabido@crg.cat
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD004284

PRIDE project URI

• PRIDE
  1. PXD004284
     1. Label: PRIDE project
     2. Name: Mouse Liver LC-MSMS - System-wide quantitative proteomics of the metabolic syndrome in mice: genotypic and dietary effects