PXD004215

PXD004215 is an original dataset announced via ProteomeXchange.

Title	p140Cap Interactome - Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
Description	p140Cap is an adapter protein that is highly expressed in the brain. In particular, p140Cap localizes at dendritic spines where it contributes to the regulation of spine shape and maturation. We recently described that p140Cap knock-out mice present cognitive deficits, impaired long-term potentiation and long-term depression, and immature filopodia-like dendritic spines, indicating that p140Cap is relevant for synaptic plasticity. Although a few p140Cap interacting proteins have been identified in the brain, a comprehensive view of its molecular partners remains largely unknown. Thus, we performed a mass spectrometry-based proteomic analysis of the p140Cap interactome.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:29:39.804.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-24 01:28:09	ID requested
1	2017-07-19 00:27:39	announced
⏵ 2	2024-10-22 04:29:41	announced	2024-10-22: Updated project metadata.

Alfieri A, Sorokina O, Adrait A, Angelini C, Russo I, Morellato A, Matteoli M, Menna E, Boeri Erba E, McLean C, Armstrong JD, Ala U, Buxbaum JD, Brusco A, Cout, é Y, De Rubeis S, Turco E, Defilippi P, Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders. Front Mol Neurosci, 10():212(2017) [pubmed]

10.3389/fnmol.2017.00212;

curator keyword: Biological, Biomedical

submitter keyword: synaptosome, nanoLC-MS/MS,p140Cap

Bruley
contact affiliation	EDyP
contact email	christophe.bruley@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD004215

PRIDE project URI

• PRIDE
  1. PXD004215
     1. Label: PRIDE project
     2. Name: p140Cap Interactome - Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders