PXD004197 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin |
Description | Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:29:39.740.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alexander Giddey |
SpeciesList | scientific name: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); NCBI TaxID: 246196; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-05-23 01:56:14 | ID requested | |
1 | 2017-03-15 08:19:01 | announced | |
⏵ 2 | 2024-10-22 04:29:41 | announced | 2024-10-22: Updated project metadata. |
Publication List
Giddey AD, de Kock E, Nakedi KC, Garnett S, Nel AJ, Soares NC, Blackburn JM, A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations. Sci Rep, 7():43858(2017) [pubmed] |
10.1038/srep43858; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Mycobacterium smegmatis tuberculosis drug resistance sub-lethal sub-MIC |
Contact List
Jonathan M Blackburn |
contact affiliation | Division of Computational and Systems Biology, Department of Integrative Biomedical Science, Faculty of Health Science, University of Cape Town, South Africa. |
contact email | jonathan.blackburn@uct.ac.za |
lab head | |
Alexander Giddey |
contact affiliation | University of Cape Town |
contact email | gddale001@myuct.ac.za |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/03/PXD004197 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004197
- Label: PRIDE project
- Name: Proteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin