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PXD004197

PXD004197 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin
DescriptionDrug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:29:39.740.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexander Giddey
SpeciesList scientific name: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155); NCBI TaxID: 246196;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-05-23 01:56:14ID requested
12017-03-15 08:19:01announced
22024-10-22 04:29:41announced2024-10-22: Updated project metadata.
Publication List
Giddey AD, de Kock E, Nakedi KC, Garnett S, Nel AJ, Soares NC, Blackburn JM, A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations. Sci Rep, 7():43858(2017) [pubmed]
10.1038/srep43858;
Keyword List
curator keyword: Biomedical
submitter keyword: Mycobacterium smegmatis tuberculosis drug resistance sub-lethal sub-MIC
Contact List
Jonathan M Blackburn
contact affiliationDivision of Computational and Systems Biology, Department of Integrative Biomedical Science, Faculty of Health Science, University of Cape Town, South Africa.
contact emailjonathan.blackburn@uct.ac.za
lab head
Alexander Giddey
contact affiliationUniversity of Cape Town
contact emailgddale001@myuct.ac.za
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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