PXD004191 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Diurnal regulatory landscape of the mouse liver nucleus |
Description | To dissect how diurnal rhythms affect key functions such as transcription or chromatin remodelling, we quantified the temporal nuclear accumulation of proteins and phosphoproteins from mouse liver using in vivo stable isotope labelling by amino acids in cell culture (SILAC)-based mass spectrometry (MS). Protein extracts from isotope labelled mice liver nuclei were used as a reference and mixed with extracts from animals collected every 3 h for 45 h total. Phosphopeptide levels were analysed after enrichment with titanium dioxide (TiO2). The proteins levels were also analysed (dataset with project accession PXD003818). |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:23:15.721.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Loïc Dayon |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue; 6x(13)C labeled residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-05-20 00:38:39 | ID requested | |
1 | 2016-12-22 01:45:22 | announced | |
2 | 2017-06-20 05:43:18 | announced | Updated project metadata. |
3 | 2017-10-24 03:13:41 | announced | Updated project metadata. |
⏵ 4 | 2024-10-22 04:23:21 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.cmet.2016.10.003; |
Wang J, Mauvoisin D, Martin E, Atger F, Galindo AN, Dayon L, Sizzano F, Palini A, Kussmann M, Waridel P, Quadroni M, Duli, ć V, Naef F, Gachon F, Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver. Cell Metab, 25(1):102-117(2017) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Phosphoproteomics, LTQ-Orbitrap, Circadian,Liver, SILAC, Nucleus |
Contact List
Frédéric Gachon |
contact affiliation | Diabetes and Circadian Rhythms Department, Nestlé Institute of Health Sciences, CH-1015 Lausanne, Switzerland |
contact email | frederic.gachon@rd.nestle.com |
lab head | |
Loïc Dayon |
contact affiliation | Nestlé Research – Nestlé Institute of Food Safety & Analytical Sciences |
contact email | loic.dayon@rd.nestle.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004191
- Label: PRIDE project
- Name: Diurnal regulatory landscape of the mouse liver nucleus