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PXD004191

PXD004191 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDiurnal regulatory landscape of the mouse liver nucleus
DescriptionTo dissect how diurnal rhythms affect key functions such as transcription or chromatin remodelling, we quantified the temporal nuclear accumulation of proteins and phosphoproteins from mouse liver using in vivo stable isotope labelling by amino acids in cell culture (SILAC)-based mass spectrometry (MS). Protein extracts from isotope labelled mice liver nuclei were used as a reference and mixed with extracts from animals collected every 3 h for 45 h total. Phosphopeptide levels were analysed after enrichment with titanium dioxide (TiO2). The proteins levels were also analysed (dataset with project accession PXD003818).
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:23:15.721.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLoïc Dayon
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; 6x(13)C labeled residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-05-20 00:38:39ID requested
12016-12-22 01:45:22announced
22017-06-20 05:43:18announcedUpdated project metadata.
32017-10-24 03:13:41announcedUpdated project metadata.
42024-10-22 04:23:21announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.cmet.2016.10.003;
Wang J, Mauvoisin D, Martin E, Atger F, Galindo AN, Dayon L, Sizzano F, Palini A, Kussmann M, Waridel P, Quadroni M, Duli, ć V, Naef F, Gachon F, Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver. Cell Metab, 25(1):102-117(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Phosphoproteomics, LTQ-Orbitrap, Circadian,Liver, SILAC, Nucleus
Contact List
Frédéric Gachon
contact affiliationDiabetes and Circadian Rhythms Department, Nestlé Institute of Health Sciences, CH-1015 Lausanne, Switzerland
contact emailfrederic.gachon@rd.nestle.com
lab head
Loïc Dayon
contact affiliationNestlé Research – Nestlé Institute of Food Safety & Analytical Sciences
contact emailloic.dayon@rd.nestle.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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