PXD004165

PXD004165 is an original dataset announced via ProteomeXchange.

Title	Identification of quantitative proteomic differences between mycobacterial lineages with altered virulence
Description	Mycobacterium tuberculosis is the causitive agent of TB, which is a global epidemic that has claimed millions of lives. Some clinical strains of M.tb have significantly more severe clinical outcomes, while some other mycobacteria ordinarily do not cause disease in humans. The biological processes underpinning this difference are poorly understood. Thus, this project aimed to identify proteomic differences between more virulent strains of the MTBC (Beijing, J37Rv, CAS and LAM) vs those strains that only cause disease in severely immune compromised humans (Bovis, Smegmatis and Avium). We hypothesise that these differences may offer insight into the molecular mechanisms by which M.tb has become more virulent by evading drug treatment or evading the host immune system more effectively.
HostingRepository	PRIDE
AnnounceDate	2016-05-23
AnnouncementXML	Submission_2016-06-17_01:59:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bridget Calder
SpeciesList	scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: 83332; scientific name: Mycobacterium bovis BCG; NCBI TaxID: 33892; scientific name: Mycobacterium tuberculosis CAS; NCBI TaxID: 1306413; scientific name: Mycobacterium avium 100; NCBI TaxID: 1235987; scientific name: Mycobacterium tuberculosis LAM7; NCBI TaxID: 746707; scientific name: Mycobacterium tuberculosis str. Beijing/W BT1; NCBI TaxID: 634955; scientific name: Mycobacterium bovis str. Ravenel; NCBI TaxID: 669465;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-17 06:25:37	ID requested
1	2016-05-23 08:38:13	announced
⏵ 2	2016-06-17 01:59:04	announced	Updated publication reference for PubMed record(s): 27303394.

Peters JS, Calder B, Gonnelli G, Degroeve S, Rajaonarifara E, Mulder N, Soares NC, Martens L, Blackburn JM, Identification of Quantitative Proteomic Differences between Mycobacterium tuberculosis Lineages with Altered Virulence. Front Microbiol, 7():813(2016) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: Mycobacteria, discovery, SRM, virulence, pathogenicity

Jonathan Blackburn
contact affiliation	Head of division: Integrative Biomedical Sciences
contact email	jonathan.blackburn@uct.ac.za
lab head
Bridget Calder
contact affiliation	University of Cape Town
contact email	bridget.calder@uct.ac.za
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/05/PXD004165

PRIDE project URI

• PRIDE
  1. PXD004165
     1. Label: PRIDE project
     2. Name: Identification of quantitative proteomic differences between mycobacterial lineages with altered virulence