PXD004105

PXD004105 is an original dataset announced via ProteomeXchange.

Title	VCP–adaptor interactions are exceptionally dynamic and subject to differential modulation by a VCP inhibitor
Description	In this study we use a combination of mass spectrometry-based proteomics and biophysical studies to characterize the interaction of adaptors with VCP. Our results reveal that most VCP–adaptor interactions are characterized by exceptionally rapid dynamics that in some cases are modulated by the VCP inhibitor NMS873. These findings have significant implications for both the regulation of VCP function and the impact of VCP inhibition on different VCP–adaptor complexes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:30:53.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liang Xue
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-05 01:49:05	ID requested
1	2016-07-18 01:01:18	announced
2	2017-06-21 00:31:29	announced	Updated project metadata.
3	2017-10-24 01:13:29	announced	Updated project metadata.
⏵ 4	2024-10-22 04:30:56	announced	2024-10-22: Updated project metadata.

Xue L, Blythe EE, Freiberger EC, Mamrosh JL, Hebert AS, Reitsma JM, Hess S, Coon JJ, Deshaies RJ, Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Mol Cell Proteomics, 15(9):2970-86(2016) [pubmed]

submitter keyword: AP-MS, SEC-MS,VCP/p97, protein complex dynamics, crosslinking-MS, Orbitrap

Raymond Deshaies
contact affiliation	California Institute of Technology
contact email	deshaies@its.caltech.edu
lab head
Liang Xue
contact affiliation	Celgene
contact email	xueliang0408@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/07/PXD004105

PRIDE project URI

• PRIDE
  1. PXD004105
     1. Label: PRIDE project
     2. Name: VCP–adaptor interactions are exceptionally dynamic and subject to differential modulation by a VCP inhibitor