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PXD004098

PXD004098 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDifferential proteomics of human seminal fluid Normo Vs Astehnozoospermia
DescriptionScarcely understood defects lead to asthenozoospermia which results in poor fertility outcomes. Incomplete knowledge of these defects hinders the development of new therapies and reliance on interventional therapies, such as in vitro fertilization, increases. Sperm cells, being transcriptionally and translationally silent, necessitate the proteomic approach to study the sperm funnction. We have performed a differential proteomics analysis of human sperm and seminal fluid and identified over 1,700 proteins. We have included 667 proteins in sperm and 430 proteins in seminal plasma dataset for further analysis. Statistical and mathematical analysis combined with pathway analysis and self organizing maps clustering and correlation was performed on the dataset. It was found that sperm proteomic signature combined with statistical analysis as opposed to the seminal plasma proteomic signature can differentiate the normozoospermic versus the asthenozoospermic sperm samples.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:29:09.684.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSakari Joenväärä
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-05-04 02:34:13ID requested
12016-12-21 04:53:19announced
22017-10-24 02:42:08announcedUpdated project metadata.
32024-10-22 04:29:13announced2024-10-22: Updated project metadata.
Publication List
Saraswat M, Joenv, ä, ä, r, ä S, Jain T, Tomar AK, Sinha A, Singh S, Yadav S, Renkonen R, Human Spermatozoa Quantitative Proteomic Signature Classifies Normo- and Asthenozoospermia. Mol Cell Proteomics, 16(1):57-72(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Human, Spermatozoa, Asthenozoospermia, Seminal Plasma
Contact List
Risto Renkonen
contact affiliationTransplantation laboratory and HUSLAB, Haartman Insititute, Univeristy of Helsinki, Finland
contact emailristo.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliationHelsinki University
contact emailsakari.joenvaara@helsinki.fi
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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