PXD004098 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Differential proteomics of human seminal fluid Normo Vs Astehnozoospermia |
Description | Scarcely understood defects lead to asthenozoospermia which results in poor fertility outcomes. Incomplete knowledge of these defects hinders the development of new therapies and reliance on interventional therapies, such as in vitro fertilization, increases. Sperm cells, being transcriptionally and translationally silent, necessitate the proteomic approach to study the sperm funnction. We have performed a differential proteomics analysis of human sperm and seminal fluid and identified over 1,700 proteins. We have included 667 proteins in sperm and 430 proteins in seminal plasma dataset for further analysis. Statistical and mathematical analysis combined with pathway analysis and self organizing maps clustering and correlation was performed on the dataset. It was found that sperm proteomic signature combined with statistical analysis as opposed to the seminal plasma proteomic signature can differentiate the normozoospermic versus the asthenozoospermic sperm samples. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:29:09.684.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sakari Joenväärä |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-05-04 02:34:13 | ID requested | |
1 | 2016-12-21 04:53:19 | announced | |
2 | 2017-10-24 02:42:08 | announced | Updated project metadata. |
⏵ 3 | 2024-10-22 04:29:13 | announced | 2024-10-22: Updated project metadata. |
Publication List
Saraswat M, Joenv, ä, ä, r, ä S, Jain T, Tomar AK, Sinha A, Singh S, Yadav S, Renkonen R, Human Spermatozoa Quantitative Proteomic Signature Classifies Normo- and Asthenozoospermia. Mol Cell Proteomics, 16(1):57-72(2017) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Human, Spermatozoa, Asthenozoospermia, Seminal Plasma |
Contact List
Risto Renkonen |
contact affiliation | Transplantation laboratory and HUSLAB, Haartman Insititute, Univeristy of Helsinki, Finland |
contact email | risto.renkonen@helsinki.fi |
lab head | |
Sakari Joenväärä |
contact affiliation | Helsinki University |
contact email | sakari.joenvaara@helsinki.fi |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004098
- Label: PRIDE project
- Name: Differential proteomics of human seminal fluid Normo Vs Astehnozoospermia