PXD004098

PXD004098 is an original dataset announced via ProteomeXchange.

Title	Differential proteomics of human seminal fluid Normo Vs Astehnozoospermia
Description	Scarcely understood defects lead to asthenozoospermia which results in poor fertility outcomes. Incomplete knowledge of these defects hinders the development of new therapies and reliance on interventional therapies, such as in vitro fertilization, increases. Sperm cells, being transcriptionally and translationally silent, necessitate the proteomic approach to study the sperm funnction. We have performed a differential proteomics analysis of human sperm and seminal fluid and identified over 1,700 proteins. We have included 667 proteins in sperm and 430 proteins in seminal plasma dataset for further analysis. Statistical and mathematical analysis combined with pathway analysis and self organizing maps clustering and correlation was performed on the dataset. It was found that sperm proteomic signature combined with statistical analysis as opposed to the seminal plasma proteomic signature can differentiate the normozoospermic versus the asthenozoospermic sperm samples.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:29:09.684.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-04 02:34:13	ID requested
1	2016-12-21 04:53:19	announced
2	2017-10-24 02:42:08	announced	Updated project metadata.
⏵ 3	2024-10-22 04:29:13	announced	2024-10-22: Updated project metadata.

Saraswat M, Joenv, ä, ä, r, ä S, Jain T, Tomar AK, Sinha A, Singh S, Yadav S, Renkonen R, Human Spermatozoa Quantitative Proteomic Signature Classifies Normo- and Asthenozoospermia. Mol Cell Proteomics, 16(1):57-72(2017) [pubmed]

curator keyword: Biological

submitter keyword: Human, Spermatozoa, Asthenozoospermia, Seminal Plasma

Risto Renkonen
contact affiliation	Transplantation laboratory and HUSLAB, Haartman Insititute, Univeristy of Helsinki, Finland
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD004098

PRIDE project URI

• PRIDE
  1. PXD004098
     1. Label: PRIDE project
     2. Name: Differential proteomics of human seminal fluid Normo Vs Astehnozoospermia