PXD004087

PXD004087 is an original dataset announced via ProteomeXchange.

Title	Protein expression in the prefrontal cortex of aged mice with progranulin deficiency or neuronal progranulin overexpression
Description	Description: Progranulin deficiency is associated with neurodegeneration in humans and in mice. We performed a deep proteomic screen of the pre-frontal cortex in aged (13-15 months) female progranulin-deficient mice (GRN-/-) and mice with a neuron-specific inducible overexpression of progranulin (SLICK-GRN-OE with tamoxifen) versus the respective control mice (Grn+/+ and SLICK-Grn without Tamoxifen). The data set shows progranulin-dependent alterations of protein expression in the cortex of mice.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:28:44.507.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-02 23:57:19	ID requested
1	2016-10-13 01:27:12	announced
⏵ 2	2024-10-22 04:28:45	announced	2024-10-22: Updated project metadata.

10.1016/j.nbd.2016.09.010;

Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, H, ä, ussler A, Albuquerque B, Zimmer B, M, ö, ser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I, Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis, 96():294-311(2016) [pubmed]

ProteomeXchange project tag: benchmarking, machine learning

curator keyword: Biological, Biomedical

submitter keyword: LC-MS/MS, mice, cortex, progranulin, neurodegeneration

Irmgard Tegeder
contact affiliation	Institute of Clinical Pharmacology, Goethe-University, Frankfurt am Main, Germany
contact email	tegeder@em.uni-frankfurt.de
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/10/PXD004087

PRIDE project URI

• PRIDE
  1. PXD004087
     1. Label: PRIDE project
     2. Name: Protein expression in the prefrontal cortex of aged mice with progranulin deficiency or neuronal progranulin overexpression