PXD004082

PXD004082 is an original dataset announced via ProteomeXchange.

Title	Data in support of Circulating neutrophil extracellular trap components including cell-free DNA are associated with neonatal sepsis and necrotizing enterocolitis in newborn, immature infants, pigs and mice
Description	Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) but specific biomarkers for diagnosis and effective treatment are lacking. Neutrophil extracellular traps (NETs) are related to sepsis in adults but not investigated in infant conditions. This is the first proteome study to document that circulating NETs are involved in neonatal LOS and NEC. cfDNA and NET proteins may provide new potential diagnostic markers for these diseases.
HostingRepository	PRIDE
AnnounceDate	2018-03-05
AnnouncementXML	Submission_2018-03-05_00:14:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Allan Stensballe
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-05-02 02:31:38	ID requested
⏵ 1	2018-03-05 00:14:01	announced

Nguyen DN, Stensballe A, Lai JC, Jiang P, Brunse A, Li Y, Sun J, Mallard C, Skeath T, Embleton ND, Berrington JE, Sangild PT, Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants. Innate Immun, 23(6):524-536(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: necrotizing enterocolitis, neutrophil extracellular traps, preterm neonates, sepsis

Allan Stensballe
contact affiliation	Laboratory for Medical Massspectroemtry
contact email	as@hst.aau.dk
lab head
Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004082
     1. Label: PRIDE project
     2. Name: Data in support of Circulating neutrophil extracellular trap components including cell-free DNA are associated with neonatal sepsis and necrotizing enterocolitis in newborn, immature infants, pigs and mice