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PXD004077

PXD004077 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative tissue proteomics analysis of primary lung adenocarcinoma
DescriptionIn this study, we generated a quantitative lung tissue proteome dataset from lung adenocarcinoma and adjacent normal lung tissues by using iTRAQ labeling combined with 2D-LC-MS/MS. Based on pathway and network analyses, protein expression profiles released in the public Human Protein Atlas database, literature search and novelty, six candidates were selected for validation via immunohistochemistry staining and western blot. Additionally, the clinical and biological significance of two novel candidates, ERO1L and NARS, was further analyzed. Collectively, our results provide a useful biomarker dataset for lung adenocarcinoma diagnosis/prognosis and provide new insights into ERO1L- and NARS- mediated tumorigenesis.
HostingRepositoryPRIDE
AnnounceDate2016-05-12
AnnouncementXMLSubmission_2016-05-12_00:53:46.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChia-Jung Yu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiTRAQ4plex-116 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-04-29 04:00:32ID requested
12016-05-12 00:53:48announced
Publication List
Hsu CH, Hsu CW, Hsueh C, Wang CL, Wu YC, Wu CC, Liu CC, Yu JS, Chang YS, Yu CJ, Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma. Mol Cell Proteomics, 15(7):2396-410(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: lung cancer
adenocarcinoma
lymph node metastasis
biomarkers
ERO1L
NARS
iTRAQ
Contact List
Chia-Jung Yu
contact affiliationChang Gung University, Taiwan
contact emailyucj1124@mail.cgu.edu.tw
lab head
Chia-Jung Yu
contact affiliation259 Wen-Hwa 1st Road, Guishan District, Tao-Yuan City, Taiwan
contact emailyucj1124@mail.cgu.edu.tw
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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