PXD004054

PXD004054 is an original dataset announced via ProteomeXchange.

Title	SILAC analysis of Δhmt1 yeast
Description	In this study, the proteome-level effects of the deletion of the gene encoding Hmt1p, the predominant yeast arginine methyltransferase, were measured using SILAC (stable isotope labeling by amino acids in cell culture), to clarify if the abundance levels of any proteins were disrupted by systemic loss of arginine methylation. Analysis revealed that numerous proteins were found to be differentially abundant between wild-type yeast and Δhmt1, and functional analysis revealed perturbation of phosphate signalling and repression of the PHO pathway.
HostingRepository	PRIDE
AnnounceDate	2018-11-21
AnnouncementXML	Submission_2018-11-21_06:21:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Yagoub
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-26 04:07:53	ID requested
⏵ 1	2018-11-21 06:21:29	announced

Chia SZ, Lai YW, Yagoub D, Lev S, Hamey JJ, Pang CNI, Desmarini D, Chen Z, Djordjevic JT, Erce MA, Hart-Smith G, Wilkins MR, Leads to the Dysregulation of Phosphate-associated Genes and Processes. Mol Cell Proteomics, 17(12):2462-2479(2018) [pubmed]

curator keyword: Biological

submitter keyword: SILAC, yeast, HMT1, arginine methylation, methylation, phosphate

Marc Roland Wilkins
contact affiliation	Systems Biology Initiative, University of New South Wales, Australia
contact email	m.wilkins@unsw.edu.au
lab head
Daniel Yagoub
contact affiliation	University of New South Wales
contact email	daniel.yagoub@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD004054

PRIDE project URI

• PRIDE
  1. PXD004054
     1. Label: PRIDE project
     2. Name: SILAC analysis of Δhmt1 yeast