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PXD004022

PXD004022 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of mitochondria isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2)
DescriptionRecently, it has been shown that mitochondrial dysfunction and oxidative stress play important roles in the pathogenesis of neurodegeneration. Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes – the end products of lipid peroxidation, is considered to exert protective function in mitochondria. The aim of our study was to use the methods of differential proteomics in concert with molecular and morphological techniques to elucidate the changes in the frontal cortex and hippocampus of apolipoprotein E knockout (apoE-/-) mice (an animal model of the early stages of Alzheimer’s disease) upon treatment with Alda-1 – a small molecular weight activator of ALDH2.
HostingRepositoryPRIDE
AnnounceDate2017-02-23
AnnouncementXMLSubmission_2017-02-23_03:48:42.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAneta Stachowicz
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-04-20 05:51:53ID requested
12017-02-23 03:48:43announced
Publication List
Stachowicz A, Olszanecki R, Suski M, G, ł, ombik K, Basta-Kaim A, Adamek D, Korbut R, Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci, 18(2):(2017) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: ALDH2, mitochondria, Alzheimer’s disease, apolipoprotein E, brain
Contact List
Rafał Olszanecki
contact affiliationChair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
contact emailmfolszan@cyf-kr.edu.pl
lab head
Aneta Stachowicz
contact affiliationJagiellonian University Medical College
contact emailstachowicz.aneta@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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