PXD004022 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of mitochondria isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2) |
Description | Recently, it has been shown that mitochondrial dysfunction and oxidative stress play important roles in the pathogenesis of neurodegeneration. Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes – the end products of lipid peroxidation, is considered to exert protective function in mitochondria. The aim of our study was to use the methods of differential proteomics in concert with molecular and morphological techniques to elucidate the changes in the frontal cortex and hippocampus of apolipoprotein E knockout (apoE-/-) mice (an animal model of the early stages of Alzheimer’s disease) upon treatment with Alda-1 – a small molecular weight activator of ALDH2. |
HostingRepository | PRIDE |
AnnounceDate | 2017-02-23 |
AnnouncementXML | Submission_2017-02-23_03:48:42.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aneta Stachowicz |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-04-20 05:51:53 | ID requested | |
⏵ 1 | 2017-02-23 03:48:43 | announced | |
Publication List
Stachowicz A, Olszanecki R, Suski M, G, ł, ombik K, Basta-Kaim A, Adamek D, Korbut R, Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci, 18(2):(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: ALDH2, mitochondria, Alzheimer’s disease, apolipoprotein E, brain |
Contact List
Rafał Olszanecki |
contact affiliation | Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland |
contact email | mfolszan@cyf-kr.edu.pl |
lab head | |
Aneta Stachowicz |
contact affiliation | Jagiellonian University Medical College |
contact email | stachowicz.aneta@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004022
- Label: PRIDE project
- Name: Proteomic analysis of mitochondria isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2)