PXD003937

PXD003937 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Gamma ray irradiation of epithelial carcinoma cells under hypoxic conditions
Description	We demonstrate for the first time that under hypoxic conditions, A431 epithelial carcinoma cells exhibit increased viability when exposed to low-dose γ-irradiation, indicating that radiotherapy can promote tumor cell survival when oxygen supply is limited. When assessed using iTRAQ quantitative proteomics and Western blotting, irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU and RCN1, suggesting important roles for these mediators in promoting tumor cell survival during hypoxia.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:49.141.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siu Kwan Sze
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-11 00:51:45	ID requested
1	2017-02-27 03:37:17	announced
⏵ 2	2024-10-22 04:04:54	announced	2024-10-22: Updated project metadata.

Publication List

Ren Y, Yeoh KW, Hao P, Kon OL, Sze SK, Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions. J Proteome Res, 15(12):4258-4264(2016) [pubmed]

Ren Y, Yeoh KW, Hao P, Kon OL, Sze SK, Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions. J Proteome Res, 15(12):4258-4264(2016) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: cancer, hypoxia,iTRAQ, radiotherapy, calcium signaling pathway

curator keyword: Biomedical

submitter keyword: cancer, hypoxia,iTRAQ, radiotherapy, calcium signaling pathway

Contact List

Newman Sze
contact affiliation	NTU
contact email	sksze@ntu.edu.sg
lab head
Siu Kwan Sze
contact affiliation	Nanyang Technical University
contact email	sksze@ntu.edu.sg
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/02/PXD003937
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/02/PXD003937

PRIDE project URI

Repository Record List

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