PXD003932

PXD003932 is an original dataset announced via ProteomeXchange.

Title	Spatial and temporal effects in protein post-translational modification distributions in the developing mouse brain
Description	Protein post-translational modification (PTM) is a powerful way to modify the behavior of cellular proteins and thereby cellular behavior. Multiple recent studies of evolutionary trends have shown that certain pairs of protein post-translational modifications tend to occur closer to each other than expected at random. This type of observation may form the basis of a proposed "PTM code", whereby protein function is controlled by complex patterns of multiple PTMs. This code could provide an additional, powerful level of regulatory control for protein function and is a plausible explanation for observations of increasingly frequent and diverse protein modification in cell biology. In this study, we use mass spectrometry and proteomic strategies to present biological data showing spatiotemporal PTM co-localization across multiple PTM categories, which display changes over development of the brain. This may be an indication of the existence of a PTM-based functional coding mechanism, which would significantly expand our view of the ways in which cells use protein PTMs in complex signaling networks.
HostingRepository	PRIDE
AnnounceDate	2016-04-11
AnnouncementXML	Submission_2016-04-11_07:58:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Veit Schwämmle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-08 08:22:20	ID requested
1	2016-04-11 05:09:17	announced
⏵ 2	2016-04-11 07:58:10	announced	Updated publication reference for PubMed record(s): 24560892, 23947802.

Edwards AV, Schw, ä, mmle V, Larsen MR, Neuronal process structure and growth proteins are targets of heavy PTM regulation during brain development. J Proteomics, 101():77-87(2014) [pubmed]

Edwards AV, Edwards GJ, Schw, ä, mmle V, Saxtorph H, Larsen MR, Spatial and temporal effects in protein post-translational modification distributions in the developing mouse brain. J Proteome Res, 13(1):260-7(2014) [pubmed]

curator keyword: Biological

submitter keyword: post-translational modifications, mouse brain, development

Martin R Larsen
contact affiliation	University of Southern Denmark
contact email	mrl@bmb.sdu.dk
lab head
Veit Schwämmle
contact affiliation	University of Southern Denmark
contact email	veits@bmb.sdu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD003932

PRIDE project URI

• PRIDE
  1. PXD003932
     1. Label: PRIDE project
     2. Name: Spatial and temporal effects in protein post-translational modification distributions in the developing mouse brain