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PXD003922

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-10-26
  • AnnouncementXML: Submission_2018-10-26_02:41:04.xml
  • DigitalObjectIdentifier: http://dx.doi.org/10.6019/PXD003922
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Supported dataset by repository
  • PrimarySubmitter: Benjamin Wolozin
  • Title: TIA1 interactome from mouse cortex
  • Description: The purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specificity of the TIA1 IP was verified by immunoblotting with anti-TIA1 antibody (Fig. 3A), and the resulting TIA1 proteome was examined by mass spectrometry.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: Phospho; Oxidation; Acetyl; Carbamidomethyl; GlyGly; Gln->pyro-Glu
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02016-04-07 04:40:22ID requested
12018-10-26 02:41:06announced

Publication List

  1. Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B, Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep, 15(7):1455-1466(2016) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Stress, stress granule, RNA binding protein, MAP, Alzheimer's disease, translational regulation, RNA metabolism

Contact List

    Benjamin Wolozin
    • contact affiliation: Depts. of Pharmacology and Neurology, Boston University School of Medicine
    • contact email: bwolozin@bu.edu
    • lab head:
    Benjamin Wolozin
    • contact affiliation: Boston University
    • contact email: bwolozin@bu.edu
    • dataset submitter:

Full Dataset Link List

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  2. PRIDE project URI
Repository Record List
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