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PXD003922

PXD003922 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTIA1 interactome from mouse cortex
DescriptionThe purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specificity of the TIA1 IP was verified by immunoblotting with anti-TIA1 antibody (Fig. 3A), and the resulting TIA1 proteome was examined by mass spectrometry.
HostingRepositoryPRIDE
AnnounceDate2018-10-26
AnnouncementXMLSubmission_2018-10-26_02:41:04.xml
DigitalObjectIdentifierhttp://dx.doi.org/10.6019/PXD003922
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterBenjamin Wolozin
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListPhospho; Oxidation; Acetyl; Carbamidomethyl; GlyGly; Gln->pyro-Glu
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-04-07 04:40:22ID requested
12018-10-26 02:41:06announced
Publication List
Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B, Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep, 15(7):1455-1466(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Stress, stress granule, RNA binding protein, MAP, Alzheimer's disease, translational regulation, RNA metabolism
Contact List
Benjamin Wolozin
contact affiliationDepts. of Pharmacology and Neurology, Boston University School of Medicine
contact emailbwolozin@bu.edu
lab head
Benjamin Wolozin
contact affiliationBoston University
contact emailbwolozin@bu.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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