PXD003922

PXD003922 is an original dataset announced via ProteomeXchange.

Title	TIA1 interactome from mouse cortex
Description	The purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specificity of the TIA1 IP was verified by immunoblotting with anti-TIA1 antibody (Fig. 3A), and the resulting TIA1 proteome was examined by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_02:41:04.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003922
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benjamin Wolozin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Phospho; Oxidation; Acetyl; Carbamidomethyl; GlyGly; Gln->pyro-Glu
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-07 04:40:22	ID requested
⏵ 1	2018-10-26 02:41:06	announced

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B, Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Rep, 15(7):1455-1466(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Stress, stress granule, RNA binding protein, MAP, Alzheimer's disease, translational regulation, RNA metabolism

Benjamin Wolozin
contact affiliation	Depts. of Pharmacology and Neurology, Boston University School of Medicine
contact email	bwolozin@bu.edu
lab head
Benjamin Wolozin
contact affiliation	Boston University
contact email	bwolozin@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD003922

PRIDE project URI

• PRIDE
  1. PXD003922
     1. Label: PRIDE project
     2. Name: TIA1 interactome from mouse cortex