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PXD003914

PXD003914 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines
DescriptionHeat-shock is an acute insult to the mammalian proteome. The sudden elevation in temperature has far-reaching effects on protein metabolism, leads to a rapid inhibition of most protein synthesis, and the induction of protein chaperones. Using heat-shock in cells of neuronal (SH-SY5Y) and glial (CCF-STTG1) lineage, in conjunction with detergent extraction and sedimentation followed by LC-MS/MS proteomic approaches, we sought to identify human proteins that lose solubility upon heat-shock.
HostingRepositoryPRIDE
AnnounceDate2016-04-11
AnnouncementXMLSubmission_2016-04-11_04:06:53.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGuilian Xu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQSTAR
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-04-06 01:32:04ID requested
12016-04-11 04:06:55announced
Publication List
Xu G, Stevens SM, Kobeissy F, Brown H, McClung S, Gold MS, Borchelt DR, Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines. PLoS One, 7(11):e49021(2012) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: SH-SY5Y, CCF-STTG1, heatshock, cultured cell, detergent insoluble
Contact List
David R. Borchelt
contact affiliationDepartment of Neuroscience, University of Florida
contact emaildrb1@ufl.edu
lab head
Guilian Xu
contact affiliationNeuroscience
contact emailxugl@ufl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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