PXD003911

PXD003911 is an original dataset announced via ProteomeXchange.

Title	Analysis of the glycoproteins present on Fasciola hepatica surface tegument
Description	Fasciola hepatica, commonly known as liver fluke, is a trematode which causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica is a complex metabolically active biological matrix that is continually exposed to the host immune system. It is highly glycosylated and parasite-derived immunogenic oligosaccharide motifs and glycoproteins are currently being investigated as novel vaccine candidates. We selectively enriched for FhTeg mannosylated glycoprotein subsets using lectin affinity chromatography and identified 369 proteins by mass spectrometric analysis.
HostingRepository	PRIDE
AnnounceDate	2016-08-03
AnnouncementXML	Submission_2016-08-03_05:10:06.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003911
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Krystyna Cwiklinski
SpeciesList	scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: 6192;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-05 09:23:32	ID requested
⏵ 1	2016-08-03 05:10:08	announced

Ravid, à A, Cwiklinski K, Aldridge AM, Clarke P, Thompson R, Gerlach JQ, Kilcoyne M, Hokke CH, Dalton JP, O'Neill SM, Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host. Mol Cell Proteomics, 15(10):3139-3153(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Fasciola hepatica, glycoproteins, tegument, lectin

Sandra O'Neill
contact affiliation	Head of School, Senior Lecturer, School of Biotechnology, Fundamental and Translational Immunology Group Leader Dublin City University, Dublin 9. Ireland
contact email	sandra.oneill@dcu.ie
lab head
Krystyna Cwiklinski
contact affiliation	Queen's University Belfast
contact email	k.cwiklinski@qub.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003911

PRIDE project URI

• PRIDE
  1. PXD003911
     1. Label: PRIDE project
     2. Name: Analysis of the glycoproteins present on Fasciola hepatica surface tegument