PXD003902

PXD003902 is an original dataset announced via ProteomeXchange.

Title	VEGF orchestration of the p130Cas Interactome
Description	p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. The work presented here was based on a collaboration between University College London and University College Dublin. Dr Ian Evans (first author) and Prof. Ian Zachary (lab head), can be contacted at: Centre for Cardiovascular Biology and Medicine, Division of Medicine The Rayne Building, University College London, London WC1E 6JJ, United Kingdom. Contact details for University College Dublin collaborators can be found below.
HostingRepository	PRIDE
AnnounceDate	2017-10-24
AnnouncementXML	Submission_2017-10-24_04:15:11.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susan Kennedy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-04-04 06:19:57	ID requested
1	2017-01-02 10:35:20	announced
2	2017-01-03 05:57:42	announced	Updated project metadata.
⏵ 3	2017-10-24 04:15:12	announced	Updated project metadata.

Evans IM, Kennedy SA, Paliashvili K, Santra T, Yamaji M, Lovering RC, Britton G, Frankel P, Kolch W, Zachary IC, Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis. Mol Cell Proteomics, 16(2):168-180(2017) [pubmed]

curator keyword: Biological

submitter keyword: IQGAP1, neuropilin, cell movement, focal adhesion, mass spectrometry

Walter Kolch
contact affiliation	Systems Biology Ireland, University College Dublin, Belfiedl, Dublin 4, Ireland
contact email	walter.kolch@ucd.ie
lab head
Susan Kennedy
contact affiliation	Systems Biology Ireland, University College Dublin.
contact email	susan.kennedy@ucd.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/01/PXD003902

PRIDE project URI

• PRIDE
  1. PXD003902
     1. Label: PRIDE project
     2. Name: VEGF orchestration of the p130Cas Interactome