PXD003870

PXD003870 is an original dataset announced via ProteomeXchange.

Title	Interactomics of the RLTPR protein explain its essential role for costimulation via CD28
Description	The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to function as an actin-uncapping protein, this property was dispensable for CD28 costimulation. Our findings underpin the convergent function of RLTPR in T cells and suggest that its scaffolding role predominates during CD28 costimulation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:03:42.442.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Camoin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-03-30 03:08:42	ID requested
1	2021-03-04 10:44:20	announced
⏵ 2	2024-10-22 04:03:48	announced	2024-10-22: Updated project metadata.

Roncagalli R, Cucchetti M, Jarmuzynski N, Gr, é, goire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B, The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med, 213(11):2437-2457(2016) [pubmed]

curator keyword: Biological

submitter keyword: Mouse, RLTPR, LC-MS/MS

Luc Camoin
contact affiliation	Marseille Proteomique, Inserm U1068, CNRS UMR 7258, Aix Marseille University UM105,
contact email	luc.camoin@inserm.fr
lab head
Luc Camoin
contact affiliation	Life Sciences
contact email	luc.camoin@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003870

PRIDE project URI

• PRIDE
  1. PXD003870
     1. Label: PRIDE project
     2. Name: Interactomics of the RLTPR protein explain its essential role for costimulation via CD28