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PXD003870

PXD003870 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInteractomics of the RLTPR protein explain its essential role for costimulation via CD28
DescriptionThe RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to function as an actin-uncapping protein, this property was dispensable for CD28 costimulation. Our findings underpin the convergent function of RLTPR in T cells and suggest that its scaffolding role predominates during CD28 costimulation.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:03:42.442.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLuc Camoin
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-03-30 03:08:42ID requested
12021-03-04 10:44:20announced
22024-10-22 04:03:48announced2024-10-22: Updated project metadata.
Publication List
Roncagalli R, Cucchetti M, Jarmuzynski N, Gr, é, goire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B, The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med, 213(11):2437-2457(2016) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Mouse, RLTPR, LC-MS/MS
Contact List
Luc Camoin
contact affiliationMarseille Proteomique, Inserm U1068, CNRS UMR 7258, Aix Marseille University UM105,
contact emailluc.camoin@inserm.fr
lab head
Luc Camoin
contact affiliationLife Sciences
contact emailluc.camoin@inserm.fr
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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