PXD003870 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interactomics of the RLTPR protein explain its essential role for costimulation via CD28 |
Description | The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to function as an actin-uncapping protein, this property was dispensable for CD28 costimulation. Our findings underpin the convergent function of RLTPR in T cells and suggest that its scaffolding role predominates during CD28 costimulation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:03:42.442.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luc Camoin |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-03-30 03:08:42 | ID requested | |
1 | 2021-03-04 10:44:20 | announced | |
⏵ 2 | 2024-10-22 04:03:48 | announced | 2024-10-22: Updated project metadata. |
Publication List
Roncagalli R, Cucchetti M, Jarmuzynski N, Gr, é, goire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B, The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med, 213(11):2437-2457(2016) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Mouse, RLTPR, LC-MS/MS |
Contact List
Luc Camoin |
contact affiliation | Marseille Proteomique, Inserm U1068, CNRS UMR 7258, Aix Marseille University UM105, |
contact email | luc.camoin@inserm.fr |
lab head | |
Luc Camoin |
contact affiliation | Life Sciences |
contact email | luc.camoin@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003870 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003870
- Label: PRIDE project
- Name: Interactomics of the RLTPR protein explain its essential role for costimulation via CD28