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PXD003865

PXD003865 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlemouse stem cell SWATH-MS .
DescriptionAdult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to SC senescence during aging. Here we demonstrate the importance of cellular NAD+ level and its impact on mitochondrial activity as a pivotal switch to modulate muscle stem cell (MuSC) senescence. Importantly, the induction of the mitochondrial unfolded protein response (UPRmt) and of prohibitin proteins, subsequent to increasing cellular NAD+ with the precursor nicotinamide riboside (NR), rejuvenates MuSCs in aged mice. NR also prevents MuSCs senescence in Mdx mice, a mouse model of muscular dystrophy. Extending these observations to other SC pools and on the organism as a whole, we demonstrate that NR delays neural stem cell (NSC) and melanocyte stem cell (McSC) senescence, while also increasing mouse lifespan. Strategies that conserve cellular NAD+ could therefore be utilized to reprogram dysfunctional SCs in aging and disease to improve lifespan in mammals
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:33:10.573.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYibo Wu
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-03-29 04:31:22ID requested
12024-10-07 10:04:16announced
22024-10-22 05:33:11announced2024-10-22: Updated project metadata.
Publication List
Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J, repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292):1436-43(2016) [pubmed]
10.1126/science.aaf2693;
Keyword List
curator keyword: Biological
submitter keyword: mouse stem cell, SWATH-MS
Contact List
Ruedi Aebersold
contact affiliationIMSB, ETH Zurich, Switzerland
contact emailaebersold@imsb.biol.ethz.ch
lab head
Yibo Wu
contact affiliationBiology
contact emailwu@imsb.biol.ethz.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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