PXD003812

PXD003812 is an original dataset announced via ProteomeXchange.

Title	Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome
Description	Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over-produced in the most lethal form of ovarian cancer, called high grade serous ovarian cancer (HGSOC). To determine its underlying molecular mechanism of action, a comprehensive analysis of KLK7 degradome in the SKOV-3 cell-secreted proteins was performed using two complementary proteomic approaches, quantitative PROtein Topography and Migration Analysis Platform (qPROTOMAP) and Terminal Amine Isotopic Labelling of Substrates (TAILS).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:08:16.024.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lakmali Munasinghage Silva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2016-03-18 01:45:59	ID requested
1	2019-02-15 07:08:22	announced
⏵ 2	2024-10-22 04:08:16	announced	2024-10-22: Updated project metadata.

Silva LM, Kryza T, Stoll T, Hoogland C, Dong Y, Stephens CR, Hastie ML, Magdolen V, Kleifeld O, Gorman JJ, Clements JA, Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome. Mol Cell Proteomics, 18(5):818-836(2019) [pubmed]

10.1074/mcp.ra118.001304;

curator keyword: Biomedical

submitter keyword: transcriptome, matrix metalloprotease, thrombospondin, protease, extracellular,Degradome, substrate, omics, microenvironment, ovarian cancer, high-grade serous, kallikrein-related peptidase, tumour

Dist Prof Judith Ann Clements
contact affiliation	Queensland University of Technology at the Translational Research Institute, Level 3 West, 37 Kent Strreet, Woolloongabba, QLD 4102 Australia
contact email	j.clements@qut.edu.au
lab head
Lakmali Munasinghage Silva
contact affiliation	Queensland University of Technology, Institute of Health and Biomedical Innovation at the Translational Research Institute
contact email	munasinghage.silva@qut.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD003812

PRIDE project URI

• PRIDE
  1. PXD003812
     1. Label: PRIDE project
     2. Name: Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome