PXD003796

PXD003796 is an original dataset announced via ProteomeXchange.

Title	Distinct Combinatorial Cascade of Events Generated by ECM Proteolysis Dictates Cell Behavior, part 2
Description	It is well established that the expression profiles of multiple and possibly redundant matrix remodeling proteases (e.g. collagenases) strongly differentiates in disease and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in-vivo activity can lead to extremely diverse tissue-remodeling outcomes. We observed that proteolysis of collagen, generated uniquely by individual homologous proteases, leads to a specific cascade of combinatorial events, which eventually affects overall extracellular matrix (ECM) topography, visco-elastic properties
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_10:50:20.734.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yishai Levin
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2016-03-16 04:33:14	ID requested
⏵ 1	2021-03-04 10:50:21	announced

Solomonov I, Zehorai E, Talmi-Frank D, Wolf SG, Shainskaya A, Zhuravlev A, Kartvelishvily E, Visse R, Levin Y, Kampf N, Jaitin DA, David E, Amit I, Nagase H, Sagi I, Distinct biological events generated by ECM proteolysis by two homologous collagenases. Proc Natl Acad Sci U S A, 113(39):10884-9(2016) [pubmed]

curator keyword: Biological

submitter keyword: ECM, proteomics

Irit Sagi
contact affiliation	Weizmann Institute of Science
contact email	irit.sagi@weizmann.ac.il
lab head
Yishai Levin
contact affiliation	Weizmann Institute of Science, Israel
contact email	yishai.levin@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003796

PRIDE project URI

• PRIDE
  1. PXD003796
     1. Label: PRIDE project
     2. Name: Distinct Combinatorial Cascade of Events Generated by ECM Proteolysis Dictates Cell Behavior, part 2