PXD003758

PXD003758 is an original dataset announced via ProteomeXchange.

Title	The dynamic interactome of Polycomb family complexes during stem cell differentiation
Description	While the core subunits of Polycomb group (PcG) complexes are well characterized, little is known about the dynamics of these protein complexes during cellular differentiation. We used quantitative interaction proteomics to study PcG proteins in mouse embryonic stem cells (mESCs) and neural progenitor cells (NPCs). We found the stoichiometry of PRC1 and PRC2 to be highly dynamic during neural differentiation.
HostingRepository	PRIDE
AnnounceDate	2016-05-24
AnnouncementXML	Submission_2016-06-17_01:58:21.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susan Kloet
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ FT; Q Exactive; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-03-09 02:02:33	ID requested
1	2016-05-24 06:07:45	announced
⏵ 2	2016-06-17 01:58:25	announced	Updated publication reference for PubMed record(s): 27294783.

Kloet SL, Makowski MM, Baymaz HI, van Voorthuijsen L, Karemaker ID, Santanach A, Jansen PWTC, Di Croce L, Vermeulen M, The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation. Nat Struct Mol Biol, 23(7):682-690(2016) [pubmed]

curator keyword: Biological

submitter keyword: PcG, PRC1, PRC2, PR-DUB

Michiel Vermeulen
contact affiliation	Department of Proteomics and Chromatin Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands
contact email	michiel.vermeulen@science.ru.nl
lab head
Susan Kloet
contact affiliation	Radboud University
contact email	s.kloet@science.ru.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/05/PXD003758

PRIDE project URI

• PRIDE
  1. PXD003758
     1. Label: PRIDE project
     2. Name: The dynamic interactome of Polycomb family complexes during stem cell differentiation