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PXD003758

PXD003758 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe dynamic interactome of Polycomb family complexes during stem cell differentiation
DescriptionWhile the core subunits of Polycomb group (PcG) complexes are well characterized, little is known about the dynamics of these protein complexes during cellular differentiation. We used quantitative interaction proteomics to study PcG proteins in mouse embryonic stem cells (mESCs) and neural progenitor cells (NPCs). We found the stoichiometry of PRC1 and PRC2 to be highly dynamic during neural differentiation.
HostingRepositoryPRIDE
AnnounceDate2016-05-24
AnnouncementXMLSubmission_2016-06-17_01:58:21.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSusan Kloet
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ FT; Q Exactive; LTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-03-09 02:02:33ID requested
12016-05-24 06:07:45announced
22016-06-17 01:58:25announcedUpdated publication reference for PubMed record(s): 27294783.
Publication List
Kloet SL, Makowski MM, Baymaz HI, van Voorthuijsen L, Karemaker ID, Santanach A, Jansen PWTC, Di Croce L, Vermeulen M, The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation. Nat Struct Mol Biol, 23(7):682-690(2016) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: PcG, PRC1, PRC2, PR-DUB
Contact List
Michiel Vermeulen
contact affiliationDepartment of Proteomics and Chromatin Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands
contact emailmichiel.vermeulen@science.ru.nl
lab head
Susan Kloet
contact affiliationRadboud University
contact emails.kloet@science.ru.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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