PXD003752 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome |
Description | Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over-produced in the most lethal form of ovarian cancer, called high grade serous ovarian cancer (HGSOC). To determine its underlying molecular mechanism of action, a comprehensive analysis of KLK7 degradome in the SKOV-3 cell-secreted proteins was performed using two complementary proteomic approaches, quantitative PROtein Topography and Migration Analysis Platform (qPROTOMAP) and Terminal Amine Isotopic Labelling of Substrates (TAILS). |
HostingRepository | PRIDE |
AnnounceDate | 2019-02-15 |
AnnouncementXML | Submission_2019-02-15_07:12:27.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD003752 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Lakmali Munasinghage Silva |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C labeled residue; monohydroxylated residue; formylated residue; iodoacetamide derivatized residue |
Instrument | mass spectrometry |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-03-08 02:04:24 | ID requested | |
⏵ 1 | 2019-02-15 07:12:28 | announced | |
Publication List
Silva LM, Kryza T, Stoll T, Hoogland C, Dong Y, Stephens CR, Hastie ML, Magdolen V, Kleifeld O, Gorman JJ, Clements JA, Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome. Mol Cell Proteomics, 18(5):818-836(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Degradome, extracellular, high-grade serous, kallikrein-related peptidase, matrix metalloprotease, microenvironment, omics, ovarian cancer, protease, substrate, thrombospondin, transcriptome, tumour |
Contact List
Dist. Prof. Judith Ann Clements |
contact affiliation | Queensland University of Technology at the Translational Research Institute, Level 3 West, 37, Kent Street, Woolloongabba, QLD, 4102, Australia |
contact email | j.clements@qut.edu.au |
lab head | |
Lakmali Munasinghage Silva |
contact affiliation | Queensland University of Technology, Institute of Health and Biomedical Innovation at the Translational Research Institute |
contact email | munasinghage.silva@qut.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003752
- Label: PRIDE project
- Name: Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome