PXD003747

PXD003747 is an original dataset announced via ProteomeXchange.

Title	Myostatin Deficiency But Not Anti-Myostatin Blockade Induces Marked Proteomic Changes in Mouse Skeletal Muscle
Description	Recent studies have reported the deleterious physiological and metabolic changes in Mstn-/- mice including impaired force generation and susceptibility to contraction-induced injury. Such observations have raised the concerns about the functional quality of the increased muscle resulting from therapeutic blockade of Mstn. Here we provide proteomic evidence to demonstrate that therapeutic Mstn inhibition has minimal effects on muscle proteome composition whereas the genetic ablation of Mstn induces marked changes. Furthermore, this study also represents the first proteomic analysis of the pharmacological blockage of the Mstn/activin receptor pathway being actively pursued as a potential therapy for multiple muscle wasting disorders.
HostingRepository	PRIDE
AnnounceDate	2016-05-31
AnnouncementXML	Submission_2016-05-31_08:24:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Robert Salzler
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	6x(13)C labeled residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-03-07 02:19:29	ID requested
⏵ 1	2016-05-31 08:24:53	announced

Salzler RR, Shah D, Dor, é A, Bauerlein R, Miloscio L, Latres E, Papadopoulos NJ, Olson WC, MacDonald D, Duan X, Myostatin deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle. Proteomics, 16(14):2019-27(2016) [pubmed]

submitter keyword: myostatin knockout, anti-myostatin blocking antibody, gastrocnemius, SILAC mouse, quantitative proteomics

Xunbao Duan
contact affiliation	Regeneron Proteomics and Biomarkers
contact email	Xunbao.duan@regeneron.com
lab head
Robert Salzler
contact affiliation	Regeneron
contact email	robert.salzler@regeneron.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/05/PXD003747

PRIDE project URI

• PRIDE
  1. PXD003747
     1. Label: PRIDE project
     2. Name: Myostatin Deficiency But Not Anti-Myostatin Blockade Induces Marked Proteomic Changes in Mouse Skeletal Muscle