PXD003663

PXD003663 is an original dataset announced via ProteomeXchange.

Title	Serum proteomics reveals a sexually dimorphic effect of vitamin D status correction on proteins of the blood coagulation pathway among overweight adults
Description	Background: An important feature to vitamin D physiology is its gender dependence. The aim of this study was to examine whether vitamin D exerts a sexually dimorphic effect on the blood coagulation pathway among adults with overweight. Methods: This study compared the serum proteomic profiles of age and BMI-matched males (n=26) and pre-menopausal females (n=24) with overweight that attained vitamin D sufficiency after a 12-month intervention. Unprocessed serum was subjected to depletion-free, quantitative proteomic analysis using our previously published methodology. Results. A total of 1,841 proteins were profiled (p < 0.05). The analysed proteins vitamin-K dependent protein C, von Willebrand factor, fibrinogen gamma chain and multimerin-1 were ELISA validated to be differentially affected between genders by vitamin D status improvement. Conclusions: Vitamin D optimization exhibits a sexually dimorphic effect on the blood coagulation pathway among adults with overweight. This gender specific vitamin D effect should be taken into consideration in the design and interpretation of vitamin D observational and intervention studies.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:08:58.511.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antigoni Manousopoulou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-18 12:22:41	ID requested
1	2016-10-13 05:53:50	announced
⏵ 2	2024-10-22 04:09:01	announced	2024-10-22: Updated project metadata.

10.1111/eci.12688;

Al-Daghri NM, Alokail MS, Manousopoulou A, Heinson A, Al-Attas O, Al-Saleh Y, Sabico S, Yakout S, Woelk CH, Chrousos GP, Garbis SD, Sex-specific vitamin D effects on blood coagulation among overweight adults. Eur J Clin Invest, 46(12):1031-1040(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: sexual dimorphism,Vitamin D, blood coagulation, serum proteomics

Spiros D. Garbis
contact affiliation	University of Southampton
contact email	sdg2e11@soton.ac.uk
lab head
Antigoni Manousopoulou
contact affiliation	University of Southampton
contact email	A.Manousopoulou@soton.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD003663
     1. Label: PRIDE project
     2. Name: Serum proteomics reveals a sexually dimorphic effect of vitamin D status correction on proteins of the blood coagulation pathway among overweight adults