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PXD003646

PXD003646 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInflammatory signaling in human Tuberculosis granulomas is spatially organized
DescriptionGranulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissection and mass spectrometry , we generated detailed molecular maps of human granulomas. We found that the centers of granulomas possess a pro-inflammatory environment characterized by anti-microbial peptides, ROS and pro-inflammatory eicosanoids. Conversely, the tissue surrounding the caseum possesses a comparatively anti-inflammatory signature.
HostingRepositoryPRIDE
AnnounceDate2016-02-26
AnnouncementXMLSubmission_2016-04-11_00:45:04.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMario Oroshi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-02-16 07:44:41ID requested
12016-02-26 01:03:56announced
22016-04-11 00:45:05announcedUpdated publication reference for PubMed record(s): 27043495.
Publication List
Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, Dartois V, Rubin EJ, Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med, 22(5):531-8(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Human, Lung, Granuloma, Mycobacterium, LC-MSMS, Q Exactive
Contact List
Matthias Mann
contact affiliationDept. Of Proteomics and Signal Transduction Max-Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried (near Munich) Germany
contact emailmmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliationProteomics
contact emailoroshi@biochem.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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