PXD003613

PXD003613 is an original dataset announced via ProteomeXchange.

Title	Comprehensive proteome profiling of platelet identified a protein profile predictive of responses to an antiplatelet agent sarpogrelate.
Description	Here, we performed a comprehensive proteome profiling of platelets collected from 18 healthy subjects before and after administration of sarpogrelate. For each subject, platelets were isolated before and then again after drug administration to investigate the alteration in the platelet proteome by sarpogrelate. A sample preparation method involving filter-aided sample preparation (FASP) was used to improve extraction of proteins including both soluble and membraneous proteins. Moreover, an ultra-high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) coupled with extensive fractionation was used to generate a comprehensive proteome of platelets.
HostingRepository	PRIDE
AnnounceDate	2016-09-29
AnnouncementXML	Submission_2016-09-29_12:04:28.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003613
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hangyeore Lee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamyl; Carbamidomethyl
Instrument	LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-11 00:58:17	ID requested
⏵ 1	2016-09-29 12:04:30	announced

Lee H, Chae S, Park J, Bae J, Go EB, Kim SJ, Kim H, Hwang D, Lee SW, Lee SY, Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate. Mol Cell Proteomics, 15(11):3461-3472(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Antiplatelet agents, LC-MS/MS, platelet proteomes, and drug responses.

Sang-Won Lee
contact affiliation	Department of Chemistry, Korea university
contact email	sw_lee@korea.ac.kr
lab head
Hangyeore Lee
contact affiliation	Korea university
contact email	hanhgr@korea.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003613

PRIDE project URI

• PRIDE
  1. PXD003613
     1. Label: PRIDE project
     2. Name: Comprehensive proteome profiling of platelet identified a protein profile predictive of responses to an antiplatelet agent sarpogrelate.