PXD003580

PXD003580 is an original dataset announced via ProteomeXchange.

Title	Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue]
Description	Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respiratory effects of a mentholated version of THS2.2 (THS2.2M) in a 90-day rat inhalation study (OECD test guideline 413). This is the quantitative proteomics data set for rat lung tissue. As described in the sample processing protocol, two different iTRAQ sets were defined and analyzed separately. See i_Rat-THS2.2M-TG413_protItraq_LeftLung.xlsx for sample annotations and file mappings.
HostingRepository	PRIDE
AnnounceDate	2017-10-24
AnnouncementXML	Submission_2017-10-24_02:38:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bjoern Titz
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-04 06:20:19	ID requested
1	2016-12-12 16:26:34	announced
⏵ 2	2017-10-24 02:38:04	announced	Updated project metadata.

Kogel U, Titz B, Schlage WK, Nury C, Martin F, Oviedo A, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J, Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke. Regul Toxicol Pharmacol, 81 Suppl 2():S123-S138(2016) [pubmed]

curator keyword: Biological

submitter keyword: reduced risk tobacco product

systems toxicology

rat inhalation study

iTRAQ

Julia Hoeng
contact affiliation	Philip Morris R&D, Neuchatel, Switzerland
contact email	julia.hoeng@pmi.com
lab head
Bjoern Titz
contact affiliation	Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland
contact email	bjorn.titz@pmi.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD003580

PRIDE project URI

• PRIDE
  1. PXD003580
     1. Label: PRIDE project
     2. Name: Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue]