PXD003555

PXD003555 is an original dataset announced via ProteomeXchange.

Title	A proteomic investigation of hepatic resistance to Ascaris in a murine model.
Description	In 2010, Ascaris caused 819 million infections worldwide. The impact on children is particularly severe, causing growth retardation and detrimental effects on cognitive development. Transmission is linked to unhygienic defecation habits, making ascariasis a disease of poverty. The WHO recognises it as one of the world's 17 neglected tropical diseases. Ascariasis is also an important parasite of pigs with economic implications including liver condemnation. Intriguingly some people (and pigs) are very heavily infected with Ascaris whereas others are not and this research aims to understand the factors that give rise to this difference and ultimately resistance to Ascaris itself. In our study we performed label free quantitative proteomics on livers of day four post infection C57BL/6J and CBA/Ca mice with and without Ascaris infection to identify proteins changes potentially linked to both resistance and susceptibility amongst the two strains, respectively. In addition tio major intrinsic differences between the two strains signatures of a differential immune response and direct modulation of host processes by the nematode were resolved.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:28:18.396.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	James Carolan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-01 06:47:21	ID requested
1	2016-08-08 10:11:14	announced
⏵ 2	2024-10-22 04:28:26	announced	2024-10-22: Updated project metadata.

10.1371/journal.pntd.0004837;

curator keyword: Biomedical

submitter keyword: Mouse, Ascaris, LFQ, Liver

James Carolan
contact affiliation	MU Applied Proteomics Lab Department of Biology Maynooth University Co Kildare, Ireland
contact email	james.carolan@nuim.ie
lab head
James Carolan
contact affiliation	Biology
contact email	james.carolan@nuim.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003555

PRIDE project URI

• PRIDE
  1. PXD003555
     1. Label: PRIDE project
     2. Name: A proteomic investigation of hepatic resistance to Ascaris in a murine model.