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PXD003555

PXD003555 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA proteomic investigation of hepatic resistance to Ascaris in a murine model.
DescriptionIn 2010, Ascaris caused 819 million infections worldwide. The impact on children is particularly severe, causing growth retardation and detrimental effects on cognitive development. Transmission is linked to unhygienic defecation habits, making ascariasis a disease of poverty. The WHO recognises it as one of the world's 17 neglected tropical diseases. Ascariasis is also an important parasite of pigs with economic implications including liver condemnation. Intriguingly some people (and pigs) are very heavily infected with Ascaris whereas others are not and this research aims to understand the factors that give rise to this difference and ultimately resistance to Ascaris itself. In our study we performed label free quantitative proteomics on livers of day four post infection C57BL/6J and CBA/Ca mice with and without Ascaris infection to identify proteins changes potentially linked to both resistance and susceptibility amongst the two strains, respectively. In addition tio major intrinsic differences between the two strains signatures of a differential immune response and direct modulation of host processes by the nematode were resolved.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:28:18.396.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJames Carolan
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-02-01 06:47:21ID requested
12016-08-08 10:11:14announced
22024-10-22 04:28:26announced2024-10-22: Updated project metadata.
Publication List
10.1371/journal.pntd.0004837;
Deslyper G, Colgan TJ, Cooper AJ, Holland CV, Carolan JC, A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model. PLoS Negl Trop Dis, 10(8):e0004837(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Mouse, Ascaris, LFQ, Liver
Contact List
James Carolan
contact affiliationMU Applied Proteomics Lab Department of Biology Maynooth University Co Kildare, Ireland
contact emailjames.carolan@nuim.ie
lab head
James Carolan
contact affiliationBiology
contact emailjames.carolan@nuim.ie
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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