PXD003555 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic investigation of hepatic resistance to Ascaris in a murine model. |
Description | In 2010, Ascaris caused 819 million infections worldwide. The impact on children is particularly severe, causing growth retardation and detrimental effects on cognitive development. Transmission is linked to unhygienic defecation habits, making ascariasis a disease of poverty. The WHO recognises it as one of the world's 17 neglected tropical diseases. Ascariasis is also an important parasite of pigs with economic implications including liver condemnation. Intriguingly some people (and pigs) are very heavily infected with Ascaris whereas others are not and this research aims to understand the factors that give rise to this difference and ultimately resistance to Ascaris itself. In our study we performed label free quantitative proteomics on livers of day four post infection C57BL/6J and CBA/Ca mice with and without Ascaris infection to identify proteins changes potentially linked to both resistance and susceptibility amongst the two strains, respectively. In addition tio major intrinsic differences between the two strains signatures of a differential immune response and direct modulation of host processes by the nematode were resolved. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:28:18.396.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | James Carolan |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-02-01 06:47:21 | ID requested | |
1 | 2016-08-08 10:11:14 | announced | |
⏵ 2 | 2024-10-22 04:28:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1371/journal.pntd.0004837; |
Deslyper G, Colgan TJ, Cooper AJ, Holland CV, Carolan JC, A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model. PLoS Negl Trop Dis, 10(8):e0004837(2016) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Mouse, Ascaris, LFQ, Liver |
Contact List
James Carolan |
contact affiliation | MU Applied Proteomics Lab Department of Biology Maynooth University Co Kildare, Ireland |
contact email | james.carolan@nuim.ie |
lab head | |
James Carolan |
contact affiliation | Biology |
contact email | james.carolan@nuim.ie |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003555 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003555
- Label: PRIDE project
- Name: A proteomic investigation of hepatic resistance to Ascaris in a murine model.