PXD003552

PXD003552 is an original dataset announced via ProteomeXchange.

Title	HCC progression
Description	Endocytosis is a cellular function which is likely to take part in HCC development due to its important role in regulating the abundances of vital signaling receptors. In this study, we aimed to investigate the expression of endocytosis-associated proteins in HCCs with various differentiation grades. Therefore, we analyzed 36 tissue specimens from HCC patients via label-free LC-MS/MS including 19 HCC tissue samples with different degrees of histological grades and 17 corresponding non-tumorous tissue controls. Following label-free analysis the abundances of SCAMP3 and CLTC were immunohistochemically examined in tissue sections of 84 HCC patients. We demonstrate the novel association of several endocytosis-associated proteins, in particular SCAMP3 with HCC progression.
HostingRepository	PRIDE
AnnounceDate	2016-09-27
AnnouncementXML	Submission_2016-09-26_22:49:29.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003552
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Wael Naboulsi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-01 03:47:13	ID requested
⏵ 1	2016-09-26 22:49:30	announced

Naboulsi W, Bracht T, Megger DA, Reis H, Ahrens M, Turewicz M, Eisenacher M, Tautges S, Canbay AE, Meyer HE, Weber F, Baba HA, Sitek B, Quantitative proteome analysis reveals the correlation between endocytosis-associated proteins and hepatocellular carcinoma dedifferentiation. Biochim Biophys Acta, 1864(11):1579-85(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Hepatocellular carcinoma, label-free proteomics, endocytosis, CLTC, SCAMP3, Liver.

Barbara Sitek
contact affiliation	Medizinisches Proteom-Center, Ruhr-Universität Bochum, 44801 Bochum, Germany
contact email	Barbara.Sitek@rub.de
lab head
Wael Naboulsi
contact affiliation	MPC
contact email	Wael.naboulsi@rub.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003552

PRIDE project URI

• PRIDE
  1. PXD003552
     1. Label: PRIDE project
     2. Name: HCC progression