PXD003457

PXD003457 is an original dataset announced via ProteomeXchange.

Title	Fibronectin-binding integrins alpha-v-beta6 and alpha9beta1 drive TGF-beta independent directional migration of head and neck carcinoma collectives through fibroblast-derived matrix
Description	For a tumor to develop and spread, the growth-repressive environment of the host tissue must undergo profound changes. These include dramatic modifications in the molecular composition and architecture of the extracellular matrix (ECM) and altered integrin expression in cancer cells to allow productive interactions. An overwhelming proportion of histopathologically invasive carcinomas, including HNSCC, retain an epithelial phenotype at invading tumor fronts. Local adhesion-dependent signals at the tumor-stroma interface can govern the different modes that tumor cells adopt to invade surrounding stroma. Defining the nature and organization of the tumor ECM and the adhesive interactions that promote cancer cell invasion is of utmost importance for tailoring effective therapies to control locoregional expansion and metastatic dissemination.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:27:32.983.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Camoin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-01-13 06:43:07	ID requested
1	2016-12-23 18:05:36	announced
2	2017-01-24 03:07:30	announced	Updated publication reference for PubMed record(s): 28102238.
⏵ 3	2024-10-22 04:27:33	announced	2024-10-22: Updated project metadata.

10.1038/ncomms14105;

Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, Camoin L, Baudelet E, Radwanska A, Beghelli-de la Forest Divonne S, Violette SM, Weinreb PH, Rekima S, Ilie M, Sudaka A, Hofman P, Van Obberghen-Schilling E, Fibronectin-guided migration of carcinoma collectives. Nat Commun, 8():14105(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: collective migration, integrins,head and neck cancer, TGF- signaling, fibronectin

Luc Camoin
contact affiliation	CRCM (Marseille Protéomique), Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université, UM105, CNRS UMR7258, Marseille
contact email	luc.camoin@inserm.fr
lab head
Luc Camoin
contact affiliation	Life Sciences
contact email	luc.camoin@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD003457

PRIDE project URI

• PRIDE
  1. PXD003457
     1. Label: PRIDE project
     2. Name: Fibronectin-binding integrins alpha-v-beta6 and alpha9beta1 drive TGF-beta independent directional migration of head and neck carcinoma collectives through fibroblast-derived matrix