PXD003451 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging |
Description | Low complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized, it remains unknown how the process of aging disturbs RBP dynamics. We show that a wide variety of RNA granule components including stress granule proteins become highly insoluble with age in C. elegans and that reduced insulin/IGF-1 daf-2 receptor signaling efficiently prevents their aggregation. Importantly, stress granule-related RBP aggregates are associated with reduced fitness. We show that HSF-1 is a main regulator of stress granule-related RBP aggregation in both young and aged animals. During aging, increasing DAF-16 activity restores dynamic stress granule-related RBPs partly by reducing the build-up of other misfolded proteins that seed RBP aggregation. Longevity-associated mechanisms found to maintain dynamic RBPs during aging could be relevant for neurodegenerative diseases. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:27:56.461.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jonathan Trinidad |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | iTRAQ4plex-116 reporter+balance reagent acylated residue |
Instrument | QSTAR |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-01-12 01:49:49 | ID requested | |
1 | 2017-01-16 14:20:57 | announced | |
⏵ 2 | 2024-10-22 04:27:58 | announced | 2024-10-22: Updated project metadata. |
Publication List
Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC, Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Cell Rep, 18(2):454-467(2017) [pubmed] |
10.1016/j.celrep.2016.12.033; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Caenorhabditis elegans, iTRAQ, quantification, aging, insulin, aggregation |
Contact List
Della C. David |
contact affiliation | German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany |
contact email | dellacdavid@gmail.com |
lab head | |
Jonathan Trinidad |
contact affiliation | Indiana University |
contact email | trinidad@indiana.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003451
- Label: PRIDE project
- Name: Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging