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PXD003419

PXD003419 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExpression changes of proteins associated with the development of preeclampsia in maternal plasma: a case control study
DescriptionDefective deep placentation, an abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetrical complications such as preeclampsia (PE), fetal growth restriction, and placental infarcts with fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce the obstetrical complications. To discover biomarkers for prediction of PE, we first performed global proteome profiling of three pairs of maternal plasma samples obtained from the early second trimester pregnant women who subsequently developed PE and controls to identify proteins that were abundant in the patients. We further evaluated the expression changes of PE representing proteins in stored plasma samples of a cohort of subsequently developed PE and their matched controls by MRM assay. We identified both Complement C1s subcomponent (p-value = 0.041) and Protein AMBP (p-value = 0.043) were up-regulated in the cohort of PE plasma samples before manifestation of clinical disease. We propose that these proteins may be involved in the remodeling process of the spiral arteries even before the manifestation of PE. These proteins could be served as potential plasma biomarkers to predict pregnant women at increased risk of developing PE.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:27:44.243.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterByoung-Kyu Cho
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-01-05 06:35:29ID requested
12018-07-05 06:08:17announced
22024-10-22 04:27:51announced2024-10-22: Updated project metadata.
Publication List
10.1002/pmic.201500381;
Kim SM, Cho BK, Kang MJ, Norwitz ER, Lee SM, Lee J, Park CW, Kim BJ, Jun JK, Park JS, Yi EC, Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study. Proteomics, 16(10):1581-9(2016) [pubmed]
Keyword List
ProteomeXchange project tag: Human Proteome Project
curator keyword: Biomedical
submitter keyword: Defective deep placentation, MRM, Preeclampsia, Physiologic transformation of spiral artery, Proteomics
Contact List
Eugene C. Yi
contact affiliationDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea
contact emaileuyi@snu.ac.kr
lab head
Byoung-Kyu Cho
contact affiliationSeoul National University
contact emailcbk562@snu.ac.kr
dataset submitter
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Dataset FTP location
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