PXD003419 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Expression changes of proteins associated with the development of preeclampsia in maternal plasma: a case control study |
Description | Defective deep placentation, an abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetrical complications such as preeclampsia (PE), fetal growth restriction, and placental infarcts with fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce the obstetrical complications. To discover biomarkers for prediction of PE, we first performed global proteome profiling of three pairs of maternal plasma samples obtained from the early second trimester pregnant women who subsequently developed PE and controls to identify proteins that were abundant in the patients. We further evaluated the expression changes of PE representing proteins in stored plasma samples of a cohort of subsequently developed PE and their matched controls by MRM assay. We identified both Complement C1s subcomponent (p-value = 0.041) and Protein AMBP (p-value = 0.043) were up-regulated in the cohort of PE plasma samples before manifestation of clinical disease. We propose that these proteins may be involved in the remodeling process of the spiral arteries even before the manifestation of PE. These proteins could be served as potential plasma biomarkers to predict pregnant women at increased risk of developing PE. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:27:44.243.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Byoung-Kyu Cho |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-01-05 06:35:29 | ID requested | |
1 | 2018-07-05 06:08:17 | announced | |
⏵ 2 | 2024-10-22 04:27:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1002/pmic.201500381; |
Kim SM, Cho BK, Kang MJ, Norwitz ER, Lee SM, Lee J, Park CW, Kim BJ, Jun JK, Park JS, Yi EC, Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study. Proteomics, 16(10):1581-9(2016) [pubmed] |
Keyword List
ProteomeXchange project tag: Human Proteome Project |
curator keyword: Biomedical |
submitter keyword: Defective deep placentation, MRM, Preeclampsia, Physiologic transformation of spiral artery, Proteomics |
Contact List
Eugene C. Yi |
contact affiliation | Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea |
contact email | euyi@snu.ac.kr |
lab head | |
Byoung-Kyu Cho |
contact affiliation | Seoul National University |
contact email | cbk562@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003419
- Label: PRIDE project
- Name: Expression changes of proteins associated with the development of preeclampsia in maternal plasma: a case control study