PXD003385 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterisation and use of orthotopically grownHapT1tumours in its homologous host as a preclinical model to evaluate novel drugs against desmoplastic pancreatic cancer |
Description | The major objective of this study was to characterise theHapT1 orthotopic hamster pancreatic tumor as a preclinical model of desmoplastic pancreatic ductal adenocarcinoma; and use this model to validate the efficacy of drugs that kills activated pancreatic stellate cells (PSCs)in vitro. Experimentaldesign: Commercially procured HapT1 pancreatic cancer (PCA) cell line was implanted in the pancreas of its syngeneic host, Syrian golden hamster (Mesocricetusauratus). After certain time period the primary and secondary tumors were harvested for histological andimmunophynotypical analysis. PSCs of hamsters were harvested, cultured and characterised. The in-cultured activated rodent PSCs and commercially procured human PSCs were used to check the cytotoxic effect of Disulfiram (DSF) in presence and absence of copper (Cu )in vitro. Finally, theHapT1 orthotopic tumor model was used to check the efficacy of DSF in vivo. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:27:33.163.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shantibhusan Senapati |
SpeciesList | scientific name: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus); NCBI TaxID: 10029; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Bruker Daltonics maXis series |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-12-23 00:33:57 | ID requested | |
1 | 2018-10-26 05:35:54 | announced | |
⏵ 2 | 2024-10-22 04:27:35 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.18632/oncotarget.9729; |
Suklabaidya S, Das B, Ali SA, Jain S, Swaminathan S, Mohanty AK, Panda SK, Dash P, Chakraborty S, Batra SK, Senapati S, Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia. Oncotarget, 7(27):41825-41842(2016) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: pancreatic cell line,Hamster, LC-MS/MS |
Contact List
Dr. Shantibhusan Senapati |
contact affiliation | Institute of life sciences (ILS) Bhubaneswar National dairy Research Institute (NDRI) Haryana, INDIA |
contact email | drsantibhusan@yahoo.com |
lab head | |
Shantibhusan Senapati |
contact affiliation | Institute of Life Sciences |
contact email | drsantibhusan@yahoo.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003385
- Label: PRIDE project
- Name: Characterisation and use of orthotopically grownHapT1tumours in its homologous host as a preclinical model to evaluate novel drugs against desmoplastic pancreatic cancer