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PXD003385

PXD003385 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterisation and use of orthotopically grownHapT1tumours in its homologous host as a preclinical model to evaluate novel drugs against desmoplastic pancreatic cancer
DescriptionThe major objective of this study was to characterise theHapT1 orthotopic hamster pancreatic tumor as a preclinical model of desmoplastic pancreatic ductal adenocarcinoma; and use this model to validate the efficacy of drugs that kills activated pancreatic stellate cells (PSCs)in vitro. Experimentaldesign: Commercially procured HapT1 pancreatic cancer (PCA) cell line was implanted in the pancreas of its syngeneic host, Syrian golden hamster (Mesocricetusauratus). After certain time period the primary and secondary tumors were harvested for histological andimmunophynotypical analysis. PSCs of hamsters were harvested, cultured and characterised. The in-cultured activated rodent PSCs and commercially procured human PSCs were used to check the cytotoxic effect of Disulfiram (DSF) in presence and absence of copper (Cu )in vitro. Finally, theHapT1 orthotopic tumor model was used to check the efficacy of DSF in vivo.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:27:33.163.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShantibhusan Senapati
SpeciesList scientific name: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus); NCBI TaxID: 10029;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentBruker Daltonics maXis series
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-12-23 00:33:57ID requested
12018-10-26 05:35:54announced
22024-10-22 04:27:35announced2024-10-22: Updated project metadata.
Publication List
10.18632/oncotarget.9729;
Suklabaidya S, Das B, Ali SA, Jain S, Swaminathan S, Mohanty AK, Panda SK, Dash P, Chakraborty S, Batra SK, Senapati S, Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia. Oncotarget, 7(27):41825-41842(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: pancreatic cell line,Hamster, LC-MS/MS
Contact List
Dr. Shantibhusan Senapati
contact affiliationInstitute of life sciences (ILS) Bhubaneswar National dairy Research Institute (NDRI) Haryana, INDIA
contact emaildrsantibhusan@yahoo.com
lab head
Shantibhusan Senapati
contact affiliationInstitute of Life Sciences
contact emaildrsantibhusan@yahoo.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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