PXD003340

PXD003340 is an original dataset announced via ProteomeXchange.

Title	human follicular fluid lc-ms/ms
Description	This study aimed to reveal if peptide profiling of individual human follicular fluid could become a new non-invasive predictive biomarker for oocyte quality, and attempted to discover candidate biomarkers for fertilization. In biomarker studies, because of normal clinical or biological variabil-ity, candidate biomarkers need to be validated across a large number of samples. To ensure that the discovered biomarkers are truly associated with oocytes quality and fertilization rather than the result of variability, three independent experiments were designed with a large population. In the present study, we investigated the peptide profile of human follicular fluid with fertilized and non-fertilized oocytes from patients undergoing in vitro fertilization using proteomic analysis with liquid chromatography-tandem mass spectrometry. We additionally determined the protein identi-ties of the discovered peptide biomarkers as a first step toward understanding the pathways in which they may function.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_03:46:47.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fang Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-12-14 06:45:07	ID requested
⏵ 1	2018-10-26 03:46:49	announced

Chen F, Spiessens C, D'Hooghe T, Peeraer K, Carpentier S, Follicular fluid biomarkers for human in vitro fertilization outcome: Proof of principle. Proteome Sci, 14():17(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: human, follicular fluid, lc-ms/ms

Carl Spiessens
contact affiliation	Leuven University Fertility Centre, UZ Leuven Campus Gasthuisberg, Herestraat 49, Leuven, Belgium.
contact email	carl.spiessens@uzleuven.be
lab head
Fang Chen
contact affiliation	Leuven University Fertility Center
contact email	fang.chen.m@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD003340

PRIDE project URI

• PRIDE
  1. PXD003340
     1. Label: PRIDE project
     2. Name: human follicular fluid lc-ms/ms