PXD003336

PXD003336 is an original dataset announced via ProteomeXchange.

Title	Xanthine Oxidoreductase mediates milk fat globule secretion.
Description	Analysis of the milk fat globule proteome from mice with a mammary-specific knockout of Xanthine Oxidoreductase.
HostingRepository	PRIDE
AnnounceDate	2017-05-31
AnnouncementXML	Submission_2017-05-31_01:53:26.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003336
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew Wither
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	DTT_C; Acetylhypusine; Trp->Asp; Ser->Arg; Trp->Pro; Biotin:Thermo-88310; VinylPMS; Cys->Gln; Thr->Ser; Lys->Thr; Decanoyl; Phenylisocyanate; Gln->Phe; Arg->Thr; DiLeu4plex; PhosphoHex; Phe->Cys; Methyl:2H(2); Thr->Glu; Val->Glu; Gln->Val; Pro->Gln; Label:2H(9)13C(6)15N(2); Ala->Glu; Tyr->Gly; Xlink:DST; Delta:H(2)C(5); Label:13C(6)15N(1); Delta:H(1)O(-1)18O(1); Asn->Glu; Phe->Gly; Diethylphosphate; Gly->Gln; Guanidinyl; Ub-Br2; Thr->His; BMP-piperidinol; Label:15N(3); DeStreak; Phe->Gln; Glu->Thr; Xle->Cys; His->Phe; His->Asn; Ser->LacticAcid; Val->Arg; Asn->Cys; Ethylphosphate; Label:13C(6)15N(2)+Dimethyl; Ala->Tyr; ISD_z+2_ion; 2-dimethylsuccinyl; Piperidine; Arg-loss; Acetyldeoxyhypusine; Tyr->Met; Delta:H(4)C(2); Xle->Glu; BITC; Didehydroretinylidene; 4-ONE; Gly->Ala; Cation:Na; Pro->Ser; Met->Gly; Phe->Thr; Met->Gln; Methyl+Deamidated; Gly->Met; HPG; Formyl; Phe->CamCys; Pro->Val; Carbamyl; Label:13C(6); Val->Lys; Phosphoguanosine; Cation:Mg[II]; Arg->Glu; Ala->Gln; Asp->Lys; Cys->Met; NDA; His->Xle; Gln->Arg; Lys->Tyr; Lys->Gly; Phe->Met; Asp->Arg; Label:13C(6)15N(4)+Dimethyl:2H(6)13C(2); Gln->Thr; NeuAc; Val->Ser; Glu->Val; Methyl:2H(3); Biotin:Thermo-33033-H; DTBP; Xlink:DSS; Lys->Asp; Pro->pyro-Glu; ICAT-D; His->Ser; Met-loss; Phe->Asp; pupylation; Acetyl; Xle->Asp; Cation:Ni[II]; Met->Trp; Nitro; Gly->Pro; Thr->Met; Xlink:DMP; Ala->Pro; Ser->Phe; HexNAc; Lys->CamCys; Val->Tyr; Pro->Phe; AEC-MAEC:2H(4); Propyl; a-type-ion; trifluoro; Thr->Arg; Xlink:DMP-de; Pro->Lys; Glu->pyro-Glu; DiLeu4plex117; OxArgBiotin; Phe->Xle; Label:13C(3)15N(1); Arg->Npo; Carboxyethyl; Hydroxymethyl; CAF; Xlink:DMP-s; NEIAA; Cys->Asp; Asn->Xle; DTT_ST:2H(6); PyruvicAcidIminyl; Isopropylphospho; His->Val; Met->Cys; Label:15N(4); Label:13C(6)+GlyGly; Phosphopropargyl; Asn->Trp; ICPL:13C(6); Delta:H(4)C(3); Didehydro; Tyr->Gln; DiLeu4plex118; Biotin:Invitrogen-M1602; Trp->Glu; NEMsulfur; SMA; AccQTag; Gln->Tyr; Val->Met; Lys-loss; Met->Ser; Label:2H(4)13C(1); Diisopropylphosphate; Tyr->Asn; Saligenin; Ala->Trp; Met->Pro; SulfanilicAcid; Delta:H(4)C(6); ethylamino; Ser->Ala; Biotin:Cayman-10141; pyrophospho; Asp->Phe; Benzoyl; Delta:H(8)C(6)O(1); glycidamide; ICPL:13C(6)2H(4); TMT; Hex; GIST-Quat:2H(9); Bromo; Trp->Tyr; Glu->Asn; DimethylamineGMBS; Xlink:EGS; Delta:H(4)C(2)O(-1)S(1); Trp->His; Label:15N(2)2H(9); CarbamidomethylDTT; Propionamide; Gln->Pro; Delta:H(6)C(3)O(1); Asn->Met; NHS-LC-Biotin; Trp->Oxolactone; Xle->Thr; Myristoyl; mTRAQ; Met->Asn; Lys->Arg; Delta:H(2)C(3); Pro->Met; Trp->Gly; Glycosyl; Lys->Cys; Xlink:EGScleaved; Thr->Lys; Cys->Val; Val->Gln; Ala->Phe; Trp->Xle; Asp->Gln; Menadione-HQ; Thr->Trp; Ala->Cys; Propionyl:13C(3); Ala->Lys; Chlorination; Arg->Phe; Trimethyl; Carboxymethyl:13C(2); Ammonia-loss; Lys->MetOx; Tyr->Phe; Lys->Val; His->Met; Ethanedithiol; Carboxy; Arg->Xle; Dicarbamidomethyl; Met->Phe; Ala->Asp; PET; Label:13C(3); NEIAA:2H(5); Palmitoleyl; Label:13C(5); Trp->Hydroxykynurenin; MG-H1; GlyGly; Phe->Ser; Label:13C(6)15N(2)+Acetyl; ICPL:2H(4); Pentylamine; glucosone; Gln->Lys; Cresylphosphate; Arg->Asp; Thiophospho; 3-deoxyglucosone; Gly->Phe; TMT2plex; Succinyl; Ammonium; Glu->Phe; Asn->Pro; Methyl:2H(3)13C(1); His->Trp; Ala->Asn; Arg; Glu->Gly; GIST-Quat; Met->Hse; Pro->Tyr; Cys->Glu; Cytopiloyne; Amidated; Tyr->Trp; Label:13C(1)2H(3); Nethylmaleimide; Lys->Pro; Ethanolyl; Glu->Xle; Gly->Val; ICDID:2H(6); Trp->Arg; Cation:Zn[II]; PEITC; Ser->Xle; Asn->Val; Succinyl:13C(4); Delta:H(8)C(6)O(2); EQAT; Asp->Trp; Met->Lys; Propionamide:2H(3); Gln->Met; Label:13C(6)15N(4)+Methyl:2H(3)13C(1); Asn->Lys; Asp->Gly; 2HPG; Xlink:SSD; Asn->Asp; Tyr->Asp; O-Dimethylphosphate; TMAB:2H(9); Cation:Ag; Ala->Val; GGQ; Glu->Gln; Label:15N(2); Arg->Asn; Met->Xle; His->Lys; Biotin-PEO-Amine; IMID; Label:13C(1)2H(3)+Oxidation; Ser->Trp; Trioxidation; ICDID; Glycerophospho; iTRAQ4plex114; Trp->Ala; Ala->Met; Xle->Phe; QEQTGG; Gly->Cys; Label:18O(1); Arg->Lys; Asp->Ser; Cation:Li; Ethyl; iTRAQ4plex; Dimethyl:2H(6)13C(2); Cation:Fe[II]; Dimethyl:2H(6); Pyridylacetyl; Dimethyl:2H(4)13C(2); Methylmalonylation; Cys->Pro; HNE-Delta:H(2)O; Trp->Thr; TNBS; Glu->Asp; His->Gly; Trp->Kynurenin; Asp->Xle; Arg->Val; Cys->Asn; Dansyl; Gly->Lys; Iminobiotin; UgiJoullieProGly; Label:15N(1); Trp->Ser; OxLysBiotinRed; Label:18O(2); Asn->Phe; Xle->Val; Ser->Asp; Acetyl:2H(3); Ser->Gly; ESP:2H(10); Biotin:Thermo-88317; Glu->Lys; probiotinhydrazide; Label:13C(6)15N(4); Met->Asp; Gln->Asn; Met-loss+Acetyl; Pro->Glu; DiLeu4plex115; Gly->Glu; Chlorpyrifos; Lysbiotinhydrazide; His->Pro; Hex(2); Phenylisocyanate:2H(5); Ser->Lys; Asn->Arg; GluGlu; ESP; Hex(1)HexNAc(2)Pent(1); CAMthiopropanoyl; Arg->Tyr; Thr->Xle; GlycerylPE; BADGE; iTRAQ4plex115; Methylpyrroline; Biotin:Thermo-21345; Gly->Asp; Asp->Ala; Lys->Met; Ser->Asn; iTRAQ8plex:13C(6)15N(2); Xle->Met; His->Cys; Cys->Xle; DTT_C:2H(6); Gln->His; dNIC; Gln->Cys; Gly->Trp; Phe->Trp; C8-QAT; Pro->Cys; ICPL; Tyr->Ala; DAET; biotinAcrolein298; CLIP_TRAQ_2; Arg->Met; BHTOH; Label:13C(9)15N(1); Pro->Ala; Val->Asn; Gly->Thr; Gln->Glu; His->Tyr; Nethylmaleimide+water; Gln->Trp; Gly->Xle; Trp->Val; Delta:H(4)C(3)O(1); Tyr->Thr; Gln->Asp; O-pinacolylmethylphosphonate; Ala->Xle; Quinone; Pro->Xle; Phe->Ala; Sulfo; His->Glu; Glu->Trp; Asp->Cys; FormylMet; Malonyl; Glu->Met; Cys->His; DMPO; Delta:H(2)C(3)O(1); Met->Ala; Xle->Pro; Lys->Ala; PhosphoUridine; IBTP; Thrbiotinhydrazide; Asn->Tyr; Pro->Asn; Delta:H(6)C(6)O(1); Label:13C(8)15N(2); Amino; Label:13C(4)+Oxidation; Arg->Gln; Dimethyl; NIPCAM; Tyr->Ser; Cation:Cu[I]; Val->Cys; Cys->Phe; Hypusine; Arg->Cys; Crotonaldehyde; Phe->His; Thioacyl; Label:13C(6)+Acetyl; mTRAQ:13C(3)15N(1); Xle->Tyr; Lys->Gln; Lys->AminoadipicAcid; Label:13C(4)15N(1); His->Gln; TMAB; Phospho; Lys->His; Arg->Gly; Tyr->Xle; Pro->Asp; Val->Phe; Ala->Ser; Val->Trp; Thr->Asn; Val->Pro; Thr->Gly; Xle->Ser; Pro->His; Palmitoyl; Xle->Trp; Pro->Thr; Methylthio; Asp->Val; Label:13C(6)15N(4)+Dimethyl; dichlorination; Carboxymethyl; 4-ONE+Delta:H(-2)O(-1); CresylSaligeninPhosphate; Asn->Gly; Asn->Gln; Cysteinyl; 3sulfo; Cation:Ca[II]; Cys->Thr; Label:13C(9); Arg->Trp; TMPP-Ac; Glu->Ser; Thr->Gln; Ala->Gly; dHex; Delta:H(2)C(2); Lys->Phe; Ser->Cys; Cys->Tyr; Glu->Cys; Asp->Met; Label:2H(4); Cys->Lys; SulfurDioxide; Ahx2+Hsl; Phe->Tyr; Asp->His; LG-Hlactam-R; Xle->Gly; Tyr->Cys; Gly->Asn; Label:13C(6)15N(2)+GlyGly; Pyridylethyl; Label:13C(6)15N(4)+Methyl; Xle->Asn; Cytopiloyne+water; Xle->Gln; Met->Val; DimethylArsino; Met->Glu; BDMAPP; Ser->Gln; Thr->Tyr; Arg2PG; Met->Arg; Arg->Ser; Delta:Se(1); Glu->Pro; HexN; Gln->Xle; IED-Biotin; Label:13C(4)15N(2)+GlyGly; Tyr->Lys; Asn->Ser; Farnesyl; Arg->Pro; LG-anhyropyrrole; Thr->Ala; Amidine; Succinyl:2H(4); Glu->Arg; TAMRA-FP; Phe->Lys; Ethyl+Deamidated; NIC; 2-nitrobenzyl; HNE; SPITC; Bromobimane; Val->Ala; Gln->Gly; Methylphosphonate; Oxidation; Xle->Arg; DFDNB; Lys->Glu; Ser->Glu; Deamidated; Hydroxyfarnesyl; Asp->Asn; Asn->Ala; Methylamine; Xle->Ala; DTT_ST; Cation:K; Gly->Arg; PyridoxalPhosphate; Ala->Thr; NO_SMX_SMCT; Argbiotinhydrazide; IMID:2H(4); Octanoyl; Asp->Glu; SecNEM; Bipyridine; Gln->pyro-Glu; His->Ala; Asp->Thr; Ser->His; Fluoro; Trp->Gln; Gln->Ser; HydroxymethylOP; Xle->His; Val->Thr; AEC-MAEC; HMVK; Ala->Arg; His->Thr; Gly; Cys->Gly; Ethanolamine; LG-lactam-R; Label:2H(4)+GlyGly; Pro->Gly; Tyr->His; PyMIC; Met->Thr; Phe->Arg; CLIP_TRAQ_4; Dimethyl:2H(4); Pyro-carbamidomethyl; Glu->Ala; Propyl:2H(6); Label:13C(6)+Dimethyl; Lys->Asn; Trp->Asn; Ser->Pro; Thr->Pro; Thr->Asp; Ser->Thr; AMTzHexNAc2; Lys->Xle; LG-anhydrolactam; Sulfide; Label:2H(10); Val->Asp; TMT6plex; Ub-amide; Menadione; Propiophenone; Delta:H(5)C(2); HCysThiolactone; Met->Tyr; Lys->Ser; Diethyl; Asp->Tyr; SulfanilicAcid:13C(6); Asp->Pro; Val->Gly; Thr->Cys; Tyr->Pro; Gln->Ala; Val->His; Ser->Tyr; Deamidated:18O(1); Label:2H(3); Leu->MetOx; Hep; Propargylamine; Sulfo-NHS-LC-LC-Biotin; Lys->Trp; Cys->Ser; Butyryl; Gly->His; Label:13C(5)15N(1); Gly->Tyr; Met->His; Phe->Glu; Deoxyhypusine; Tyr->Glu; Phosphoadenosine; UgiJoullieProGlyProGly; cGMP+RMP-loss; Propionyl; Glu->Tyr; CLIP_TRAQ_3; Glu->His; Cys->Ala; Biotin:Thermo-33033; Phe->Asn; O-Isopropylmethylphosphonate; Methyl; AEBS; Dihydroxyimidazolidine; Phe->Val; Tyr->Val; Ser->Val; Ethoxyformyl; His->Arg; Label:13C(9)+Phospho; Pro->Arg; Ser->Met; Gly->Ser; Can-FP-biotin; Glu; iTRAQ8plex; Thr->Val; BHAc; mTRAQ:13C(6)15N(2); Pro->Trp; Val->Xle; Asn->His; Xle->Lys; Thr->Phe; Arg->His; thioacylPA; Nmethylmaleimide; Ala->His; Phe->Pro; Arg->Ala; DimethylpyrroleAdduct; G-H1; Label:2H(4)+Acetyl; Asn->Thr; maleimide; Furan; O-Methylphosphate; HCysteinyl; Biotin; Dioxidation; Cys->Arg; Carbofuran
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-12-14 05:23:00	ID requested
⏵ 1	2017-05-31 01:53:27	announced

Monks J, Dzieciatkowska M, Bales ES, Orlicky DJ, Wright RM, McManaman JL, Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion. J Physiol, 594(20):5899-5921(2016) [pubmed]

curator keyword: Biological

submitter keyword: xanthine oxidoreductase, mouse, lactation, lipid droplet, milk fat globule, apocrine secretion, proteomics, LC-MS/MS

Jenifer Monks
contact affiliation	Dept. of Obstetrics & Gynecology University of Colorado, Anschutz Medical Campus
contact email	jenifer.Monks@ucdenver.edu
lab head
Matthew Wither
contact affiliation	University of Colorado Denver
contact email	matthew.wither@ucdenver.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD003336

PRIDE project URI

• PRIDE
  1. PXD003336
     1. Label: PRIDE project
     2. Name: Xanthine Oxidoreductase mediates milk fat globule secretion.