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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2017-07-17
  • AnnouncementXML: Submission_2017-07-17_03:56:40.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Melanie Hillion
  • Title: Monitoring global protein thiol-oxidation and protein S-mycothiolation in Corynebacterium diphtheriae under hypochlorite stress
  • Description: Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol peroxidase Tpx, the mycothiol peroxidase Mpx and the methionine sulfoxide reductase MsrA. Here we investigated the level of protein S-mycothiolation in Corynebacterium diphtheriae DSM43989 under oxidative stress as well as its NaOCl stress response.
  • SpeciesList: scientific name: Corynebacterium diphtheriae; NCBI TaxID: 1717;
  • ModificationList: L-cystine (cross-link); cysteinylation (disulfide with free L-cysteine); Applied Biosystems cleavable ICAT(TM) heavy; N-ethylmaleimide derivatized cysteine; Applied Biosystems cleavable ICAT(TM) light; monohydroxylated residue
  • Instrument: LTQ Orbitrap Velos

Dataset History

VersionDatetimeStatusChangeLog Entry
02015-12-10 06:49:26ID requested
12017-07-17 03:56:41announced

Publication List

  1. Hillion M, Imber M, Pedre B, Bernhardt J, Saleh M, Loi VV, Maaß S, Becher D, Astolfi Rosado L, Adrian L, Weise C, Hell R, Wirtz M, Messens J, Antelmann H, The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress. Sci Rep, 7(1):5020(2017) [pubmed]

Keyword List

  1. curator keyword: Biological, Biomedical
  2. submitter keyword: oxidative stress, bacteria, corynebacterium diphtheria, mycothiol, OxICAT, S-mycothiolation

Contact List

    Haike Antelmann
    • contact affiliation: Freie Universität Berlin Institut für Biologie-Mikrobiologie Königin-Luise-Straße 12-16 14195 Berlin Germany
    • contact email: haike.antelmann@fu-berlin.de
    • lab head:
    Melanie Hillion
    • contact affiliation: FU Berlin
    • contact email: melanie.hillion@fu-berlin.de
    • dataset submitter:

Full Dataset Link List

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  2. PRIDE project URI
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