PXD003230

PXD003230 is an original dataset announced via ProteomeXchange.

Title	Whole saliva baseline proteome profile - head and neck cancer
Description	Oral mucositis (OM) is a common, painful and often treatment-limiting side effect of radiotherapy (RT) for head and neck cancer (HNC) patients. Unstimulated saliva was collected before the first radiotherapy application in 50 HNC patients. 41 out of 50 patients developed OM (grade III) during radiotherapy, of which 14 patients even displayed an early OM (grade III) at low radiation dose of 30 Gy. Nine patients did not develop OM (grade III). Using an LC-MS/MS approach 5,323 tryptic peptides were assigned to 487 distinct proteins (≥2 peptides) in the data set. The levels of 48 proteins differed significantly (p<0.05) between patients developing OM or not. 17 proteins displayed increased levels (≥1.3-fold) and 31 proteins decreased in level in OM, respectively. Furthermore, using partial least square analysis proteins patterns could be used to distinguish subjects which did not develop grade III OM even after 70 Gy total dose (n=9) and those displaying early OM (grade III at <30 Gy total dose, n=14). Using leave one out cross validation 37 of 41 patients (90%) developing OM could be correctly assigned indicating that prognostic proteome signatures may help to identify patients that should be specifically monitored to increase overall effectiveness of RT treatment.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:27:09.550.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nico Jehmlich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-11-24 23:45:28	ID requested
1	2016-07-04 02:49:32	announced
⏵ 2	2024-10-22 04:27:21	announced	2024-10-22: Updated project metadata.

10.1016/j.jprot.2015.04.030;

Jehmlich N, Stegmaier P, Golatowski C, Salazar MG, Rischke C, Henke M, V, ö, lker U, Differences in the whole saliva baseline proteome profile associated with development of oral mucositis in head and neck cancer patients undergoing radiotherapy. J Proteomics, 125():98-103(2015) [pubmed]

Jehmlich N, Stegmaier P, Golatowski C, Salazar MG, Rischke C, Henke M, V, ö, lker U, Proteome data of whole saliva which are associated with development of oral mucositis in head and neck cancer patients undergoing radiotherapy. Data Brief, 8():501-5(2016) [pubmed]

10.1016/j.dib.2016.05.053;

curator keyword: Biomedical

submitter keyword: LC-MS/-MS,Whole saliva

Uwe Völker
contact affiliation	University Medicine Greifswald Interfaculty Institute for Genetics and Functional Genomics Department of Functional Genomics Friedrich-Ludwig-Jahn-Str. 15a 17475 Greifswald, Germany
contact email	voelker@uni-greifswald.de
lab head
Nico Jehmlich
contact affiliation	Helmholtz-Centre for Environmental Research - UFZ
contact email	nico.jehmlich@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/07/PXD003230

PRIDE project URI

• PRIDE
  1. PXD003230
     1. Label: PRIDE project
     2. Name: Whole saliva baseline proteome profile - head and neck cancer