PXD003183 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of multiple transferrin species in spleen from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with the disease activity. Role of CD38. Citrullinated Proteins |
Description | Collagen type II-induced arthritis (CIA) is an autoimmune disease that is accompanied by a complex host systemic response, which includes inflammatory and autoimmune reactions. Since to develop CIA is required the injection of antigen in complete Freund’s adjuvant (CFA), which is a water-in-mineral-oil emulsion containing killed Mycobacteria, systemic response proteins related with inflammation can confound the detection or diagnosis of arthritis. CIA in CD38 deficient mice (CD38 KO) is milder than that in C57BL/6 (B6 WT) mice. Protein extracts from spleen were subjected to 2D-DiGE and MS-MALDI-TOF/TOF analysis to identify proteins that were differentially expressed in CD38 KO and B6 WT mice with arthritis, with inflammation, or non-immunized. Differential protein expression was validated by ELISA, or Western-blotting. |
HostingRepository | PRIDE |
AnnounceDate | 2015-12-11 |
AnnouncementXML | Submission_2015-12-11_02:03:42.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD003183 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Antonio Rosal-Vela |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | deamidated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | 4800 Proteomics Analyzer; ultraflex |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-11-12 03:46:52 | ID requested | |
⏵ 1 | 2015-12-11 02:03:43 | announced | |
Publication List
Rosal-Vela A, Barroso A, Gim, é, nez E, Garc, í, a-Rodr, í, guez S, Longobardo V, Postigo J, Iglesias M, Lario A, Merino J, Merino R, Zubiaur M, Sanz-Nebot V, Sancho J, Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38. J Proteomics, 134():127-137(2016) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Citrullinated Proteins, CD38, Protein Species, CIA, 2D-DiGE, Rheumatoid Arthritis, Spleen |
Contact List
Jaime Sancho Lopez |
contact affiliation | Instituto de Parasitología y Biomedicina "López - Neyra", CSIC Departamento de Biología Celular e Inmunología Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento, s/n 18016, Granada-Spain |
contact email | granada@ipb.csic.es |
lab head | |
Antonio Rosal-Vela |
contact affiliation | PostDoc researcher |
contact email | arosal@ipb.csic.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003183
- Label: PRIDE project
- Name: Identification of multiple transferrin species in spleen from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with the disease activity. Role of CD38. Citrullinated Proteins