PXD003169

PXD003169 is an original dataset announced via ProteomeXchange.

Title	Host-microbiota interactions in the pathogenesis of antibiotic-associated diseases:C. difficile infection
Description	Improved understanding of the interplay between host and microbes stands to illuminate new avenues for disease diagnosis, treatment and prevention. Here, we provide a high-resolution view of the dynamics between host and gut microbiota during antibiotic induced intestinal microbiota depletion, opportunistic Salmonella typhimurium and Clostridium difficile pathogenesis, and recovery from these perturbed states in a mouse model. Host-centric proteome and microbial community profiles provide an unprecedented longitudinal view revealing the interdependence between host and microbiota in evolving dysbioses. Time- and condition-specific molecular and microbial signatures are evident and clearly distinguished from pathogen-independent inflammatory fingerprints. Our data reveal that mice recovering from antibiotic treatment or C. difficile infection retain lingering signatures of inflammation despite compositional normalization of the microbiota, and host responses could be rapidly and durably relieved through fecal transplant. These experiments define a novel platform for combining orthogonal, untargeted approaches to shed new light on the gastrointestinal ecosystem.
HostingRepository	PRIDE
AnnounceDate	2016-02-04
AnnouncementXML	Submission_2016-02-04_07:34:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joshua Elias
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-11-10 01:25:22	ID requested
⏵ 1	2016-02-04 07:34:09	announced

Lichtman JS, Ferreyra JA, Ng KM, Smits SA, Sonnenburg JL, Elias JE, Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases. Cell Rep, 14(5):1049-1061(2016) [pubmed]

curator keyword: Biomedical, Metaproteomics

submitter keyword: mouse, gut microbiome, antibiotic, c difficile, fecal transplant

Joshua E Elias
contact affiliation	Department of Chemical & Systems Biology, Stanford University
contact email	josh.elias@stanford.edu
lab head
Joshua Elias
contact affiliation	Chemical & Systems Biology
contact email	josh.elias@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD003169

PRIDE project URI

• PRIDE
  1. PXD003169
     1. Label: PRIDE project
     2. Name: Host-microbiota interactions in the pathogenesis of antibiotic-associated diseases:C. difficile infection