PXD003120

PXD003120 is an original dataset announced via ProteomeXchange.

Title	Downregulation of LATS kinases alters p53 to promote cell migration
Description	p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53’s conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator.
HostingRepository	PRIDE
AnnounceDate	2018-10-25
AnnouncementXML	Submission_2018-10-25_01:17:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yair Pozniak
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-10-29 03:21:20	ID requested
⏵ 1	2018-10-25 01:17:07	announced

Furth N, Bossel Ben-Moshe N, Pozniak Y, Porat Z, Geiger T, Domany E, Aylon Y, Oren M, Down-regulation of LATS kinases alters p53 to promote cell migration. Genes Dev, 29(22):2325-30(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: TP53, Cox-2, cancer, cell-migration, NFKB2, homeostasis

Tamar Geiger
contact affiliation	The Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
contact email	geiger@tauex.tau.ac.il
lab head
Yair Pozniak
contact affiliation	Tel Aviv University
contact email	yair.poz@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD003120

PRIDE project URI

• PRIDE
  1. PXD003120
     1. Label: PRIDE project
     2. Name: Downregulation of LATS kinases alters p53 to promote cell migration