PXD003094

PXD003094 is an original dataset announced via ProteomeXchange.

Title	Comprehensive proteomic comparision between native tendon and ligament and 3D issue engineered tendon and ligament constructs
Description	Tendons and ligaments are important biological structures in both human and animals. They are part of dense connective tissue and are crucial to the functioning of the musculoskeletal system. However, they are commonly damaged due to age-related wear and tear, trauma or sports related incidents, which can lead to severe immobility for the individual and can lead to injury of other tissues and development of degenerative joint disease such as osteoarthritis. Tissue engineering can offer great potential in the treatment of tendon and ligament injury by seeking a biological replacement with fully regenerated autologenous tissue. This approach commonly involves an artificial ECM (scaffold) on which cell can proliferate and differentiate with subsequent new tissue generation. Fibrin is a natural scaffold with no expected toxic degradation or inflammatory reaction and can be used as an autologous scaffold for fibroblast from connective tissue to create a three dimensional structure. The purpose of this study was to compare the proteomic differences between native tendon, ligament and 3D tissuen engineered tendon and ligament fibrin constructs.
HostingRepository	PRIDE
AnnounceDate	2016-06-27
AnnouncementXML	Submission_2016-06-27_06:21:28.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003094
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yalda Ashraf
SpeciesList	scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-10-21 14:30:41	ID requested
⏵ 1	2016-06-27 06:21:30	announced

Kharaz YA, Tew SR, Peffers M, Canty-Laird EG, Comerford E, Proteomic differences between native and tissue-engineered tendon and ligament. Proteomics, 16(10):1547-56(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: native tendon, native ligament, 3D tissue engineered tendon, 3D tissue engineered ligament

EIthne Comerford
contact affiliation	Head musculoskeletal skeletal biology department, institute of ageing and chronic disease, University of Liverpool, UK
contact email	eithne.comerford@liv.ac.uk
lab head
Yalda Ashraf
contact affiliation	University of Liverpool
contact email	yalda@liverpool.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD003094
     1. Label: PRIDE project
     2. Name: Comprehensive proteomic comparision between native tendon and ligament and 3D issue engineered tendon and ligament constructs