PXD003075

PXD003075 is an original dataset announced via ProteomeXchange.

Title	Human CSF peptidomics of gamma secretase inhibition
Description	Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the γ-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by liquid chromatography coupled to mass spectrometry, using isobaric labeling based on the tandem mass tag approach for relative quantification.
HostingRepository	PRIDE
AnnounceDate	2016-03-15
AnnouncementXML	Submission_2016-03-14_17:27:57.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD003075
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Johan Gobom
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; 6x(13)C labeled residue; TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-10-19 01:48:30	ID requested
⏵ 1	2016-03-14 17:27:58	announced

H, ö, ltt, ä M, Dean RA, Siemers E, Mawuenyega KG, Sigurdson W, May PC, Holtzman DM, Portelius E, Zetterberg H, Bateman RJ, Blennow K, Gobom J, -secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans. Alzheimers Res Ther, 8(1):11(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, cerebrospinal fluid, peptidomics, gamma secretase

Johan Gobom
contact affiliation	Institute of Neuroscience and Physiology Section of psychiatry and neurochemistry University of Gothenburg
contact email	johan.gobom@neuro.gu.se
lab head
Johan Gobom
contact affiliation	Institute of Neuroscience and Physiology
contact email	johan.gobom@neuro.gu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD003075

PRIDE project URI

• PRIDE
  1. PXD003075
     1. Label: PRIDE project
     2. Name: Human CSF peptidomics of gamma secretase inhibition