PXD003003

PXD003003 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterisation of extracellular vesicles derived from first trimester placentae
Description	This study investigated the proteomes of macro-, micro- and nanovesicles derived from the same first trimester human placenta to better understand the role that these extracellular vesicles (EVs) play in maternal adaptation during healthy pregnancy. During human pregnancy, the mother undergoes major physiological and immunological adaptations to accommodate the fetus. There is growing evidence that EVs extruded from the placental syncytiotrophoblast into the maternal blood may regulate these maternal adaptations. Placental EVs can be divided into macro-, micro- and nanovesicles based on their size. To date, it is unclear whether these differently sized EVs carry different protein cargos and have different effects on maternal responses.
HostingRepository	PRIDE
AnnounceDate	2016-04-29
AnnouncementXML	Submission_2016-04-29_00:54:14.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Torsten Kleffmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-10-05 01:21:30	ID requested
⏵ 1	2016-04-29 00:54:16	announced

Tong M, Kleffmann T, Pradhan S, Johansson CL, DeSousa J, Stone PR, James JL, Chen Q, Chamley LW, Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication. Hum Reprod, 31(4):687-99(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: macrovesicles, microvesicles, nanovesicles, pregnancy, syncytiotrophoblast

Larry Chamley
contact affiliation	Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
contact email	l.chamley@auckland.ac.nz
lab head
Torsten Kleffmann
contact affiliation	Department of Biochemistry, University of Otago, Dunedin, New Zealand
contact email	torsten.kleffmann@otago.ac.nz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD003003

PRIDE project URI

• PRIDE
  1. PXD003003
     1. Label: PRIDE project
     2. Name: Proteomic characterisation of extracellular vesicles derived from first trimester placentae