PXD002958

PXD002958 is an original dataset announced via ProteomeXchange.

Title	Mouse Skin LC-MS/MS .
Description	Previously, we reported that a null mutation of the Zdhhc13 gene caused by ethylnitrosourea (ENU) mutagenesis in mice resulted in severe systematic phenotypes with amyloidosis, alopecia, dermatitis and osteoporosis. In this study we continued to delineate the pathological mechanism for the dermatitis phenotype and to explore potential palmitoylation substrates of ZDHHC13, which potentially explain the loss-of-function phenotype of ZDHHC13 in skin. Our data clearly suggested that protein S-palmitoylation of a constellation of skin barrier components by ZDHHC13 is crucial for their protein stability, functions, and overall barrier integrity.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:02:51.757.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi-Ju Chen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	N-ethylmaleimide derivatized cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-09-22 01:52:37	ID requested
⏵ 1	2024-10-07 10:02:52	announced

10.1016/j.jid.2019.09.017;

Chen LY, Lin KR, Chen YJ, Chiang YJ, Ho KC, Shen LF, Song IW, Liu KM, Yang-Yen HF, Chen YJ, Chen YT, Liu FT, Yen JJY, Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. J Invest Dermatol, 140(5):959-970.e3(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Mouse Skin tissue, palmitoylation, LC-MS/MS

Yi-Ju Chen
contact affiliation	Institute of Chemistry, Academia Sinica
contact email	tp7249@gmail.com
lab head
Yi-Ju Chen
contact affiliation	Academia Sinica
contact email	tp7249@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD002958

PRIDE project URI

• PRIDE
  1. PXD002958
     1. Label: PRIDE project
     2. Name: Mouse Skin LC-MS/MS