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PXD002958

PXD002958 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse Skin LC-MS/MS .
DescriptionPreviously, we reported that a null mutation of the Zdhhc13 gene caused by ethylnitrosourea (ENU) mutagenesis in mice resulted in severe systematic phenotypes with amyloidosis, alopecia, dermatitis and osteoporosis. In this study we continued to delineate the pathological mechanism for the dermatitis phenotype and to explore potential palmitoylation substrates of ZDHHC13, which potentially explain the loss-of-function phenotype of ZDHHC13 in skin. Our data clearly suggested that protein S-palmitoylation of a constellation of skin barrier components by ZDHHC13 is crucial for their protein stability, functions, and overall barrier integrity.
HostingRepositoryPRIDE
AnnounceDate2024-10-07
AnnouncementXMLSubmission_2024-10-07_10:02:51.757.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYi-Ju Chen
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListN-ethylmaleimide derivatized cysteine; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-09-22 01:52:37ID requested
12024-10-07 10:02:52announced
Publication List
10.1016/j.jid.2019.09.017;
Chen LY, Lin KR, Chen YJ, Chiang YJ, Ho KC, Shen LF, Song IW, Liu KM, Yang-Yen HF, Chen YJ, Chen YT, Liu FT, Yen JJY, Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. J Invest Dermatol, 140(5):959-970.e3(2020) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Mouse Skin tissue, palmitoylation, LC-MS/MS
Contact List
Yi-Ju Chen
contact affiliationInstitute of Chemistry, Academia Sinica
contact emailtp7249@gmail.com
lab head
Yi-Ju Chen
contact affiliationAcademia Sinica
contact emailtp7249@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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