PXD002943

PXD002943 is an original dataset announced via ProteomeXchange.

Title	Quantitative analysis of SUMO1 and SUMO2 proteomes in human lung A549 cells during influenza A virus infection or heat-shock
Description	Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damageand DNA virus infections. Here, we describe the host SUMOylation response to the nuclear-replicating RNA pathogen, influenz A virus. Using quantitative proteomics to compare SUMOylation responses to various stresses (including heat-shock), we reveal that influenza A virus infection causes unique re-targeting of SUMO1 and SUMO2 to a diverse range of host proteins involved in transcription, mRNA processing, RNA quality control and DNA damage repair. This global characterization of influenza virus-triggered SUMO remodeling provides a proteomic resource to understand host nuclear SUMOylation responses to infection.
HostingRepository	PRIDE
AnnounceDate	2015-11-05
AnnouncementXML	Submission_2015-11-10_02:38:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Filip Golebiowski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	sumoylated lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-09-18 04:22:45	ID requested
1	2015-11-05 08:02:43	announced
⏵ 2	2015-11-10 02:38:51	announced	Updated publication reference for PubMed record(s): 26549460.

Domingues P, Golebiowski F, Tatham MH, Lopes AM, Taggart A, Hay RT, Hale BG, Global Reprogramming of Host SUMOylation during Influenza Virus Infection. Cell Rep, 13(7):1467-1480(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: SUMO, influenza, heat-shock, virus, infection, ubiquitin, stress

Benjamin Geoffrey Hale
contact affiliation	Institute of Medical Virology University of Zürich Winterthurerstrasse 190 8057 Zürich Switzerland
contact email	hale.ben@virology.uzh.ch
lab head
Filip Golebiowski
contact affiliation	University of Zurich
contact email	golebiowski.filip@virology.uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/11/PXD002943

PRIDE project URI

• PRIDE
  1. PXD002943
     1. Label: PRIDE project
     2. Name: Quantitative analysis of SUMO1 and SUMO2 proteomes in human lung A549 cells during influenza A virus infection or heat-shock